The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Biomarkers to Support Therapeutic Trials Program, 2025Ultra-sensitive Quantification of Phosphorylated LRRK2 in Biofluids from Clinical Trials of Therapeutic Candidates
Study Rationale: LRRK2 is a protein for which inappropriate activation is associated with Parkinson’s disease (PD). Investigators are therefore pursuing the activity of LRRK2 as a potential...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Elucidating the Role of PINK1 and PRKN in Cell Type-specific Responses to Alpha-synuclein Pathology
Study Rationale: Parkinson’s disease (PD) is associated with loss of dopamine neurons and aggregation of the protein alpha-synuclein. Mutations that impair the function of PINK1 and PRKN, proteins...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Accelerating Biological Understanding and Therapeutic Translation for PD-Biology
Study Rationale: Mutations in the PINK1 and Parkin genes cause early-onset Parkinson’s disease (PD). In rats with similar mutations in PINK1 and Parkin, we observed pronounced degeneration of nerve...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Identifying Biochemical, Histological and Molecular Signatures of Constipation Associated with Parkinson’s Disease
Study Rationale: Constipation is one of the most common non-motor symptoms of Parkinson’s disease (PD). It occurs in 50 to 80 percent of people with PD and doubles the risk of PD diagnosis after 10...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2025Studying SCAMPs: Membrane Proteins that Control Trafficking of Alpha-synuclein
Study Rationale: Parkinson’s disease (PD) progresses with the death of nerve cells in the brain. Some forms of the disease run in families due to mutations in important genes. One of these genes...
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iPSC Phenotyping Environmental Exposure Program, 2025Screening the Functional Impact of Environmental Chemicals on Human Neurons and Astrocytes in Culture
Study Rationale: With growing global concerns about environmental chemicals acting as a trigger of Parkinson's disease (PD), we will assess the affect such molecules have on the electrical activity...
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Our funding programs support basic, translational and clinical research from academia and industry.