The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2011Nmnat Function in Axonal Neuroprotection
Promising Outcomes of Original Grant:
In the previous application, we tested the hypothesis that gene delivery of NMNAT-1 would protect striatal innervation in 6-OHDA lesioned pre-clinical models and... -
Repositioning Drugs for PD, 2011Droxidopa Treatment for Cognitive Impairment in Parkinson's Disease
Objective/Rationale:
Memory, concentration, and other cognitive operations are sometimes impaired in Parkinson's disease (PD), but available treatment options are very limited. This project will test... -
Rapid Response Innovation Awards, 2011Pathogenic Significance of the Hyperpolarization-activated Current (Ih) in the Degeneration of Dopaminergic Neurons
Objective/Rationale:
The neurotoxin MPTP is believed to kill nigral dopaminergic neurons by inhibiting mitochondrial metabolism, thus producing Parkinson’s signs in pre-clinical models. Recent studies... -
MJFF Research Grant, 2011GeneGo LRRK2 Pathway Map - Laura Brovold (GeneGo/Thomson Reuters)
Objective/Rationale:
Human diseases are inherently complex and involve a multitude of interconnected proteins, which function in groups defined as pathways and complexes. In order to understand... -
Dyskinesia, 2011Role of Gad1 in l-DOPA-induced dyskinesias
Objective/Rationale:
Levodopa remains the most efficient agent used for the Symptoms & Side Effects treatment of Parkinson’s disease. Unfortunately, levodopa administration for several years also... -
MJFF Research Grant, 2011Estimating Neuroprotective Effects of Nigral AAV-NRTN Using Selective Reaction Monitoring to Quantitatively Measure p-erk1/2 Signaling Strength in Nigral DA Neurons
Objective/Rationale:
Pre-clinical studies indicate that neurotrophic factor gene therapy has the potential to attenuate, delay and perhaps prevent the progressive loss of nigral DA neurons in aging...
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Our funding programs support basic, translational and clinical research from academia and industry.