The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Dyskinesia, 2011Development of a Treatment for Dyskinesia Targeting Opioid Receptors
Objective/Rationale:
Levodopa-induced dyskinesias (LID) affect the majority of patients with advanced Parkinson’s disease, compounding their disability. Therefore, drugs that prevent or limit LID are... -
Rapid Response Innovation Awards, 2011Novel Neuroprotective Cell-Penetrating Peptides
Objective/Rationale:
Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) is currently one of the most potent factors protecting and rescuing neurons in pre-clinical models of Parkinson’s... -
Research Grant, 2011Comparing Cognitive Scales in the MUSTARDD-PD Study
Objective/Rationale:
Some people with Parkinson’s may develop dementia during their disease course. Being able to detect problems with mental function at an early stage, to monitor and to reliably... -
Rapid Response Innovation Awards, 2011Testing Novel Compounds for Noninvasive Delivery of Small Interfering RNA into CNS
Objective/Rationale:
Small interfering RNA (siRNA) molecules have been successfully used to target specific genes in cell culture. However, the lack of specificity for siRNA to cells and lack of...
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MJFF Research Grant, 2011Phenotypic Characterization of BAC LRRK2 Transgenic Pre-clinical Models
Objective/Rationale:
Mutations in the protein leucine-rich repeat kinase 2 (LRRK2) are the most common cause of inherited Parkinson’s disease (PD). Interestingly, the penetrance LRRK2 mutations and...
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Rapid Response Innovation Awards, 2011Fractalkine-CX3Cr1 Signaling in Models of Parkinson Disease: Quest for Novel Therapeutic Strategies
Objective/Rationale:
Microglia, one of the key players in neuroinflammation, are increased in number and activated in the brains of Parkinson’s disease (PD) or pre-clinical models of PD. A recent...
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Our funding programs support basic, translational and clinical research from academia and industry.