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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Dyskinesia Challenge, 2013
    Deciphering the Role of Histone Deacetylase in Levodopa-Induced Dyskinesia

    Objective/Rationale:
    It is well known that repeated administration of levodopa causes gradual changes in striatal gene expression that eventually result in the development of levodopa-induced...
    Researchers:

    Olivier Berton, PhD | Erwan Bezard, PhD

    Details
  • Dyskinesia Challenge, 2013
    Imaging Dyskinesia in People with Parkinson's Disease

    Objective/Rationale:             
    Levodopa-induced dyskinesias are abnormal involuntary movements that may develop with levodopa therapy for Parkinson's disease (PD). Recent studies on pre-clinical...
    Researchers:

    Ken Herrmann, MD | Ioannis Ugo Isaias, MD, PhD | David Eidelberg, MD

    Details
  • LRRK2 Pharmacodynamic Assays, 2013
    LRRK2-associated Mitochondrial DNA Damage as a Phenotype for Unbiased Screening

    Objective/Rationale:  
    The normal functions of LRRK2 are poorly understood, and the mechanism(s) by which LRRK2 mutations cause PD are unclear. Also, therapeutic development has been hampered by the...
    Researchers:

    J. Timothy Greenamyre, MD, PhD

    Details
  • Biosample and Tissue Resource, 2013
    Is Dysphagia in Parkinson’s Disease Caused by Lewy Pathology in the Upper Aerodigestive Tract?

    Objective/Rationale:             
    We have recently demonstrated that the nerves supplying the throat are directly affected in Parkinson’s disease (PD) by the same microscopic process that affects the...
    Researchers:

    Liancai Mu, MD, PhD

    Details
  • Research Grant, 2013
    Virtual Research Visits

    Objective/Rationale:             
    The Michael J. Fox Foundation’s Fox Trial Finder is designed to facilitate and increase the participation of individuals with Parkinson’s disease in clinical trials...
    Researchers:

    Ray Dorsey, MD, MBA | Kevin M. Biglan, MD, MPH

    Details
  • Research Grant, 2013
    Long-term Cortical Recording in Parkinson’s Disease Patients Using a Totally Implanted Device

    Objective/Rationale:             
    Deep brain stimulation (DBS) of basal ganglia structures is an effective treatment for Parkinson’s disease (PD). However, its mechanism of action is still unclear...
    Researchers:

    Coralie de Hemptinne, PhD | Philip Starr, MD, PhD | Jill Ostrem, MD

    Details
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