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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2007
    Genetic characterization of Omi/Htra2 (PARK13) in autosomal dominant and sporadic Parkinson’s disease

    Objective/Rationale: 

    Identification of DNA variations that cause familial/sporadic parkinsonism has provided insight into the biological pathways involved in disease. Thirteen loci (PARK1-13) have...

  • Target Validation, 2007
    Development of Lentiviral DN-TNF Vectors: A Novel Anti-inflammatory Gene Therapy to Block Nigrostriatal Degeneration

    Objective/Rationale:

    A growing number of epidemiological and experimental animal studies implicate neuroinflammatory mechanisms in the progressive death of midbrain dopamine (DA) neurons in Parkinson’s...

  • Clinical Intervention Awards, 2007
    Serotonin and Sleep Disordered Breathing in Parkinson Disease

    Objective/Rationale:
    Sleep related problems are a major cause of impairment in Parkinson's disease. Recent studies indicate a high incidence of a disabling sleep disorder – sleep disordered breathing...

  • Clinical Intervention Awards, 2007
    The PARKFIT Study: Effectiveness of an Active Lifestyle Promotion Program for Patients with Parkinson’s disease

    Objective/Rationale:
    Parkinson's patients are inclined toward a sedentary lifestyle. This is due to a combination of both physical handicaps (e.g. walking difficulties) and mential impairments (e.g...

  • Clinical Intervention Awards, 2007
    Helicobacter Pylori Eradication and Motor Fluctuations in Parkinson's Disease

    Objective/Rationale:
    Helicobacter pylori is a common bacterial infection often associated with disorders of the gastrointestinal tract. Treatment of H. pylori in patients with Parkinson’s disease has...

  • Clinical Intervention Awards, 2007
    NH004 Films for Sialorrhea in PD Patients (2007)

    Objective/Rationale:
    The goal of the research is to advance the clinical development of NH004 for the control of sialorrhea (excessive drooling or uncontrolled salivation). NH004 is a dissolving film...

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