The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Alpha-synculein Biology and Therapies, 2018Supporting Alpha-synuclein Attachment to Synaptic Vesicles for the Treatment of Parkinson's Disease
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). Researchers believe that alpha-synuclein clumps can damage nerve cells in the... -
Research Grant, 2018Autophagy and Mitochondrial Dysfunction as Potential Therapeutic Targets in Inherited Parkinson's Disease
Study Rationale:
Mutations (changes) in the gene that controls the production of enzyme glucocerebrosidase (GCase) are the most common risk factor for inherited Parkinson's disease (PD). We have... -
Research Grant, 2018Assessing Proteins LRRK2, GCase and Cytokines in Immune Cells
Study Rationale:
Leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are two proteins linked to an increased risk of developing Parkinson’s disease (PD). Both proteins are produced by... -
Target Advancement Program, 2017Toll-like Receptor Inhibition to Block Alpha-synuclein-induced Pro-inflammatory Signaling and Cytokine Release
Study Rationale:
Synucleinopathies, including Parkinson's disease (PD), are a family of central nervous system (CNS) degenerative disorders characterized by alpha-synuclein protein-containing... -
Improved Biomarkers and Clinical Outcome Measures, 2017Dopamine Buffering Capacity Measured by phMRI as a Novel Biomarker of Disease Progression in Parkinson's Disease
Study Rationale:
This project will test a new idea for measuring the severity of Parkinson's disease (PD). The brain acts as if it can store each dose of levodopa (L DOPA) for a short period of time... -
Research Grant, 2017Improving Participation in Clinical Trials in Individuals with Atypical Parkinsonian Syndromes through Virtual Research Visits (ImPaCT-Atypical)
Objective/Rationale:
The Michael J. Fox Foundation's Fox Trial Finder is designed to facilitate and increase the participation of individuals with Parkinson's disease (PD) and degenerative...
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Our funding programs support basic, translational and clinical research from academia and industry.