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Funded Studies

Manoj Kumar Pandey, BSc, MSc, PhD

Research Instructor at Cincinnati Children’s Hospital Medical Center

Location: Cincinnati, OH United States

Dr. Manoj Pandey (PhD) is a faculty member in Division of Human Genetics at Cincinnati Children’s Hospital Medical Center (CCHMC) in Ohio. He trained  under world-renowned investigators in the fields of cancer (Dr. Russel, Mayo Clinic), complement (Dr Köhl, CCHMC), and lysosomal storage diseases (Dr. Grabowski, CCHMC). He became an independent investigator in 2014, and his research has been funded by MJFF, Alexion, UC, and CCHMC. Dr Pandey has given award-winning presentations at conferences on immunology, neurology, and inborn errors of metabolism. He discovered that in Gaucher’s disease, autoantibodies that recognize glucosylceramide, a component of cell membranes, triggers the activation of complement protein C5a, which sparks tissue inflammation (Pandey et al, Nature 2017).

Associated Grants

  • Assessing Inhibition of a Protein of the “Complement System” to Reduce Brain Inflammation and Neuronal Loss in People with Parkinson’s Disease


  • GBA Defects Cause C5a-C5aR1-induced Neurodegeneration in Parkinson’s Disease


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