The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Access to Data and Biospecimens, 2017LRRK2 in predicting Parkinson disease risk and progression in LRRK2 mutation carriers
Study Rationale:
The G2019S mutation in the LRRK2 gene is responsible for thousands Parkinson disease (PD) cases. But, not all of the mutation carriers will develop PD. Currently, clinicians...
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Research Grant, 2016Investigation of the Role of PINK1-dependent Phosphorylation of Rab GTPases in Parkinson’s Disease
Study Rationale:
Mutations in the PINK1 gene lead to Parkinson’s disease. PINK1 belongs to a special class of enzymes known as protein kinases. We recently found that PINK1 targets a family of enzymes... -
Priority Target Award, 2016Advancing PINK1 Knockout Models of Parkinson’s
Study Rationale:
Loss-of-function mutations in PINK1 are causally linked to early-onset Parkinson’s disease (PD). MJFF funded the generation and initial characterization of PINK1 knockout (KO) models... -
Research Grant, 2016Production of Helper Dependent Adenovirus Type 5 LRRK2 Expression Vectors
Study Rationale:
The LRRK2 gene has been implicated in Parkinson’s disease, but is too large to be expressed in viral vectors, a tool to modify cells. In order to study LRRK2... -
Target Advancement Program, 2016Biochemical Analysis and Structural Determination of LRRK2 with Kinase Inhibitors
Study Rationale:
Although pharmacological and surgical treatments are available to manage the symptoms of Parkinson’s disease (PD), none yet can slow down or stop the course of the... -
Improved Biomarkers and Clinical Outcome Measures, 2016Developing a Molecular Imaging Tool That Binds to Alpha-Synuclein and Inhibits Its Formation
Study Rationale:
Amyloid fibrils play a key role in Parkinson's disease (PD). Studying their formation from self‐assembled aggregates (protein clumps) would help aid the development of a valuable...
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Our funding programs support basic, translational and clinical research from academia and industry.