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Funded Studies
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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Improved Biomarkers and Clinical Outcome Measures, 2015
    Eye Tracking as a Biomarker for Manifest and Prodromal Parkinson’s Disease

    Study Rationale:                   
    Over the past 14 years, we have utilized sophisticated commercial eye movement monitoring equipment to collect data from over 3300 participants. Our work aims to...
    Researchers:

    Mark S. Baron, MD | Paul A. Wetzel, PhD | Jorge L. Juncos, MD | Ergun Yasar Uc, MD

    Details
  • Therapeutic Pipeline Program, 2015
    Alpha4Beta2 Nicotinic Agonist for Treatment of L-Dopa Refractory Gait and Balance Disorders in Parkinson Disease

    Study Rationale:
    Gait and balance problems, particularly falls, are common and disabling symptoms in Parkinson disease (PD), and do not improve markedly with existing treatments. Studies have indicated...
    Researchers:

    Roger L. Albin, MD | William T. Dauer, MD

    Details
  • Target Validation, 2015
    Validating the Neuroprotective Enzyme ACMSD as a Novel Therapeutic Target in Parkinson's Disease by Viral Vector-Mediated Overexpression

    Study Rationale:                             
    A number of genetic studies have linked variation in the enzyme aminocarboxy-muconate semialdehyde decarboxylase (ACMSD) with a risk for Parkinson’s...
    Researchers:

    Lena Cecilia Brundin, MD, PhD | Patrik Brundin, MD, PhD

    Details
  • Improved Biomarkers and Clinical Outcome Measures, 2015
    Defining a PD-specific Breath Fingerprint of Underlying Inflammatory and Neurodegenerative Processes

    Study Rationale:                   

    Breath analysis has the potential to be a powerful non-invasive screening tool to help a clinician determine the need for additional more invasive tests, a tool...
    Researchers:

    Malú G. Tansey, PhD | Charlene Warres Bayer, PhD

    Details
  • Research Grant, 2015
    Neurorestorative Effects of a Sigma-1 Receptor Agonist in a Model of Parkinson’s Disease

    Study Rationale:                   
    In a previous MJFF-sponsored project, we evaluated PRE-084 (an experimental compound binding to the sigma-1 receptor) in pre-clinical models of Parkinson’s disease...
    Researchers:

    M. Angela Cenci Nilsson, MD, PhD | Christopher U. Missling, PhD, MBA

    Details
  • Research Grant, 2015
    Development of a Radioligand for Imaging of Alpha-synuclein with Positron Emission Tomography

    Study Rationale:                   
    The visualization of alpha-synuclein deposition in the living human brain is of high need as a biomarker for Parkinson´s disease (PD). Positron emission tomography...
    Researchers:

    Andrea Varrone, MD, PhD

    Details
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Our funding programs support basic, translational and clinical research from academia and industry.

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