The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2015Assay-PoC for the Reduction of Endogenous Alpha-synuclein Levels in iPS-PD Neurons
Study Rationale:
Accumulation of the alpha-synuclein protein in the brain of individuals with Parkinson’s disease (PD) is a hallmark of the disease, and mutations in the... -
Therapeutic Pipeline Program, 2015Inhibitors of Alpha-synuclein Oligomers for the Treatment of Parkinson’s Disease
Study Rationale:
The alpha-synuclein protein forms oligomers (protein clumps) that cause toxicity in the brains of individuals with Parkinson’s disease (PD). We have developed methods that can measure... -
Biomarker Development, 2015Development of Novel, Small Molecule Compounds as PET Tracers for Synucleinopathies
Study Rationale:
Our project aims to develop a brain imaging agent for alpha-synuclein, a key protein involved in Parkinson’s disease (PD) pathology. Such an agent will help (i) diagnose PD earlier,... -
Access to Data and Biospecimens, 2015Lysosomal Enzyme Activity and GBA1 Genotyping in Parkinson’s Disease
Study Rationale:
The dysfunction of the systems responsible for the clearance of the protein alpha-synuclein plays a major role in Parkinson’s disease (PD). The lysosome is an... -
Therapeutic Pipeline Program, 2015Utilization of Aptamers to Prevent Protein Aggregation in Parkinson’s Disease
Objective/Rationale:
The abnormal aggregation of a protein known as alpha-synuclein appears to play a critical role in Parkinson's disease. This project will explore a new type of... -
Target Validation, 2015Targeting the NLRP3 Inflammasome in Models of Parkinson's Disease
Objective/Rationale:
Chronic inflammation within the brain is emerging as a possible driver in the progression of Parkinson’s disease (PD). Inflammasomes are protein complexes that...
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Our funding programs support basic, translational and clinical research from academia and industry.