The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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The Role of Inflammation in Parkinson's Disease, 2003Activation of neuroinflammatory glial response by neuromelanin, its role in neurodegeneration, and therapeutic strategies for Parkinson's disease
In Parkinson's disease a preferential loss of neurons containing neuromelanin occurs with respect to the neurons which do not contain neuromelanin. We have previously shown that neuromelanin inside...
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Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2003Mechanisms of Graft-Induced Dyskinesias in an Animal Model of Parkinson's Disease
Embryonic dopamine neurons can be transplanted to the region of the brain that becomes depleted of dopamine in Parkinson's disease (PD). Studies performed in both patients and animal models of PD have...
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Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2003The Role of Abnormal Gap Junction Communication in the Generation of Levodopa-induced Dyskinesia in Parkinson's Disease
We hypothesize that enhanced gap junction communication (GJC) plays an unheralded and important role in the neural mechanisms underlying levodopa-induced dyskinesia (LID). Gap junctions are a special...
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Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2003A Trial of Low Frequency Repetitive Transcranial Magnetic Stimulation for Treatment of Dyskinesia
Levodopa-induced dyskinesia (LID) is a major source of disability of many patients with Parkinson's disease (PD). LID may be associated with increased activity of the part of the brain that mediates...
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Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2003Anatomical and neurochemical characterization of basal ganglia neuropeptides in levodopainduceddyskinesia
The most common treatment for Parkinson's disease is levodopa (L-DOPA). This usually gives good relief of symptom for many years but, eventually, complications such as abnormal involuntary movements...
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Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2003Reversal of Dyskinesias By in-vivo Gene Transfer of L-DOPA Using Adeno-associated Viral Vectors
Parkinson's disease is a result of an extensive loss of the pigmented neurons located in the brain stem (termed the Substantia Nigra). These nerve cells are the principal neurons producing dopamine in...
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Our funding programs support basic, translational and clinical research from academia and industry.