Funding Opportunities
Objective:
This program seeks to accelerate clinical therapeutic development of interventions that may reduce, slow or prevent disabling motor or non-motor symptoms of Parkinson’s disease not well managed by current treatments.
Funding will support clinical projects aimed at progressing promising interventions with strong preclinical packages into/through initial clinical assessment exploring pharmacokinetics and pharmacodynamics, safety/tolerability, or early proof of clinical efficacy.
MJFF will prioritize proposals with the strongest translational potential, therapeutic rationale and patient value, fulfilling the following criteria:
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Selected therapeutic target/pathway or mechanism shows a strong biological rationale to be pursued as a therapeutic target in PD.
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The proposal emphasizes a translational biomarker development plan (where applicable), including measures to monitor target engagement/modulation, hypothesized mechanism of action and patient enrichment measures that can improve clinical trial design to de-risk further development.
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The proposal has a patient centered approach incorporating patient voice in the clinical development plan.
For this round, MJFF will not consider:
- Pre-clinical applications.
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Applications for target identification, proposing early discovery studies to identify new targets.
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Applications testing tool compounds or biological manipulations with no viable path for further drug optimization/development.
The Parkinson’s Disease Clinical Therapeutics Pipeline Program works in two stages with the goal of offering applicants frequent chances to propose promising therapeutics:
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Applicants may submit a pre-proposal application at any time for initial consideration by MJFF within three weeks from submissions.
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Applicants whose pre-proposal is selected for further consideration will be invited to submit a full proposal to one of our upcoming review cycles, at least six weeks from the date of invitation.
Applicants will be notified of a decision within 3 months of the full proposal submission period. Office hours are available for applicants invited to submit a full proposal to discuss program fit and proposal development.
NOTE: Applicants are permitted to submit multiple, unique therapeutic pre-proposals but should NOT submit multiple pre-proposals supporting different stages or aspects of the same therapeutic development program. Applicants are also permitted and encouraged to re-submit a revised pre-proposal that addresses prior feedback provided by MJFF, if applicable.