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MJFF Scientific Publications & Clinician Articles

The Michael J. Fox Foundation continually strives to communicate our scientific progress with the research community — through posters and presentations at meetings, in peer-reviewed scientific publications and with white paper reports.

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    The Michael J. Fox Foundation’s Strategy to Generate, Characterize, and Distribute Preclinical Alpha-Synuclein Research Tools for Molecular Biology

    Mutations in the gene SNCA that encodes the protein alpha-synuclein as well as postmortem pathological studies strongly implicate a general role for alpha-synuclein in Parkinson’s disease (PD)…

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    Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

    Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Wing-Lok Ho, Shu-Leong Ho, Alastair D Reith, Dario R Alessi Autosomal…

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    Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Martin Steger, Francesca Tonelli, Genta Ito, Paul Davies, Matthias Trost, Melanie Vetter, Stefanie Wachter, Esben Lorentzen, Graham Duddy, Stephen Wilson, Marco AS Baptista, Brian K Fiske, Matthew J…

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    Targeting GBA1 for Parkinson's disease research

    Kuldip D. Dave1, Adria K. Martig1, Terina N. Martinez1, Lee J. Pellegrino2, Leo B. Dungan2, Rick Hamler2, Sean W. Clark2, Peter D. Buckett3, Yi Chen3, Weisong Shan3, Warren D. Hirst3, Michael Sasner4…

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    LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences

    Marco A.S. Baptista1, Kalpana M. Merchant1, Sakshi Bharghava2, Diane Bryce3, Michael Ellis3, Anthony A. Estrada4, Matthew Fell3, Reina N. Fuji4, Paul Galatsis2, Sue Hill3, Warren D. Hirst2,…

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    Histological and clinical pathology findings in LRRK2-related mouse and rat models

    Terina N. Martinez1, Marco A.S. Baptista1, Melanie A. Greeley2, Mark T. Herberth2, Daniel Kovarik1, Adria Martig1, Kuldip D. Dave1,Mark A. Frasier1, Brian Fiske1, and Todd Sherer1Affiliations: The…

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    Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

    Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and…

Articles authored by Rachel Dolhun, MD, a movement disorder specialist on staff at MJFF, offer a practical review of topics related to Parkinson's disease for practicing clinicians.

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Breaking Research Updates

Read the latest developments in the field’s understanding and treatment of Parkinson’s disease.

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