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Overview of LRRK2 Models

The mutations in the LRRK2 gene which increase the LRRK2 kinase activity are a common genetic form of Parkinson’s disease (PD). The most common mutation is the G2019S mutation which increases kinase activity ~1.5 fold. The R1441C/G mutation increases kinase activity ~4-fold. There are a number of models available to study LRRK2-related mutations/function. In the attached summary you will find a list of those that are commonly used. Please note, this list is by no means comprehensive -- others are available that may suit your needs.

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