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Overview of Mitochondrial Dysfunction Models

Mitochondrial function is a pathway of great interest for Parkinson’s disease (PD) research and therapeutic development given the dysfunction that has been observed in idiopathic patients, patients with mutations in parkin/PINK1 genes, and mechanism of action for known environment toxins linked to PD. Mitochondrial dysfunction is observed in many PD models. In this overview document you will find a summary of models that use mitochondrial dysfunction to drive pathology. Please note, this list is not comprehensive.

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