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Overview of PINK1 Models

Mutations in the PTEN-induced kinase 1 (PINK1)  gene cause autosomal recessive, young onset Parkinson’s disease (PD). The PD-linked mutations in PINK1 lead to loss of expression/function of the PINK1 protein, which is a kinase that localizes to mitochondria and phosphorylates ubiquitin and Parkin. PINK1 has been shown to function in mitophagy and in restraining immune responses. Preclinical models for PINK1-linked PD are based on reducing or eliminating the activity of the PINK1 protein, either through genetic knockout or knockin of loss-of-function mutations. This overview document contains commonly used animal models of PD linked to PINK1 mutations. Please note, this list is by no means comprehensive.

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