To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
-
Sponsored Tools Program
Learn more about how MJFF can help share your tools.
-
Tools Consortium
MJFF is working with industry to develop priority tools.
-
Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
AAV Scrambled Control 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV scrambled control 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194249
Lentiviral LRRK2 (G2019S/D1994A)
Viral Vector
Lentiviral vector expressing LRRK2 mutated at residues G2019S and D1994A. Lentiviral eGFP available as a control in Reporter section.
Please note: This viral vector is not intended for in vivo use.
Alpha-Synuclein Preformed Fibril Protein*
Protein
Aggregated alpha-synuclein protein intended for use in synuclein seeding experiments.
Total Rab 10 Antibody
Antibody
Mouse anti-Rab10 antibody that has undergone Fc species switching to develop mouse reagents from the original rabbit antibody (MJF-R23). The new chimeric antibody is approved for immunoblotting, immunocytochemistry, and immunoprecipitation and can be detected using Fc-specific secondary antibodies to mouse IgG.
Alpha-Synuclein Antibody
Antibody
Mouse anti-alpha-synuclein antibody that has undergone Fc species switching to develop mouse reagents from the original rabbit antibody (MJFR1). The new chimeric antibody is approved for immunoblotting and immunohistochemistry and can be detected using Fc-specific secondary antibodies to mouse IgG.
Mouse/Human pS129 Alpha-Synuclein Assay
Assay
AlphaLISA® SureFire® Ultra™ immunoassay kit for detection of Human and Mouse alpha-synuclein phosphorylated at S129 (pS129 aSyn).
Mouse/Human Total Alpha-Synuclein Assay
Assay
AlphaLISA® SureFire® Ultra™ immunoassay kit for detection of Human and Mouse total alpha-synuclein.
BAC-Alpha Synuclein*
Mouse Model
Mice conditionally express wild-type human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028806
BAC-Alpha Synuclein 120*
Mouse Model
Mice conditionally express mutant human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene that produces a C-terminal truncated protein. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028808
Rab 10 pT73 Phosphospecific Antibody
Antibody
Mouse anti-pT73 Rab10 antibody that has undergone Fc species switching to develop mouse reagents from the original rabbit antibody (MJF-R21). The new chimeric antibody is approved for immunoblotting and immunocytochemistry and can be detected using Fc-specific secondary antibodies to mouse IgG.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic