To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Rab 10 pT73 Phosphospecific Antibody
Antibody
Mouse anti-pT73 Rab10 antibody that has undergone Fc species switching to develop mouse reagents from the original rabbit antibody (MJF-R21-22-5). The new chimeric antibody is approved for immunoblotting and immunocytochemistry and can be detected using Fc-specific secondary antibodies to mouse IgG.
Ubiquitin pS65 Phosphospecific Antibody (Ms ELISA)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine65 of mouse ubiquitin. Suitable for ELISA applications. Detailed characterization data is published in Watzlawik et al, Autophagy 2024.
Cell line stably expressing wildtype LRRK2 (Type: Raw 264.7 macrophages)
Immortalized Cell
Wildtype LRRK2 parental Raw 264.7 macrophage cell line to be used as a control with the mutant LRRK2 T1348N (KI) or LRRK2 (KO) macrophages.
Human GCase Antibody (ICC)
Antibody
Monoclonal mouse anti-human GCase antibodies (clones 1/17 and 1/23) for immunocytochemistry applications.
These antibodies were generated by Roche and are kindly made available to academic/non-profit organizations only through the MJFF Sponsored Tools Program.
LysoFQ-GBA FQ6 (Lysosomal GCase Probe Green)*
Assay
This GCase activity probe is a cell-permeable reporter for GCase activity, fluoresces upon glucocerebrosidase activation, facilitating the detection and monitoring of GBA1 activity. These probes were generated and kindly shared through the MJFF Sponsored Tools Program by David Vocadlo.
INPP5F Knockout HeLa Cell Line
Immortalized Cell
HeLa cell with homozygous knockout of INPP5F.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Alpha-Synuclein Filament-Specific Antibody
Antibody
Conformation-specific rabbit monoclonal antibody directed against the filamentous form of wild-type alpha-synuclein.
LRRK2 pT2483 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine 2483 of LRRK2.
Acid Ceramidase (ASAH1) Antibody
Antibody
Rabbit monoclonal antibody directed against human acid ceramidase for immunocytochemistry and immunoprecipitation applications.
MCU Floxed DAT-Cre Mouse*
Mouse Model
MCU Floxed DAT-Cre mice were generated by crossing floxed exons 5 and 6 of the MCU gene (Zampese et al. 2022) with mice expressing Cre recombinase under the dopaminergic-specific DAT to induce knock-out of MCU (mitochondrial Ca2+ uniporter), resulting in the loss of MCU specifically in dopaminergic cells. Model was designed by D. James Surmeier at Northwestern University and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038988
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic