To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Parkin/PINK1 Double KO Rat
Rat Model
Breeding of the CRISPR Parkin KO Sprague Dawley rat with the CRISPR PINK1 KO Sprague Dawley rat to create a line with homozygous deletion of both genes.
Estimated Availability: Mid 2026
DOX-Inducible iPSC-Derived Dopamine Neuron
Human iPS Cell
Inducible iPSC line in which addition of doxicycline to the media stimulates differentiation into dopamine neurons with 90% purity in a matter of days.
Estimated Availability: Mid 2026
Total Rab 29 Antibody (Hu)
Antibody
Rabbit monoclonal antibody directed against the human total Rab 29 protein. Suitable for immunoblot and immunoprecipitation experiments. This antibody epitope was mapped to amino acids 141-150.
Miro1 Antibody (WB)
Antibody
Rabbit monoclonal antibody directed against human/mouse/rat Miro1, validated for use as a detector antibody in immunoblotting applications.
LRRK2 N2081D KI Mouse*
Mouse Model
Mice expressing the conserved LRRK2 N2081D variant introduced to exon 41 of the mouse Lrrk2 gene using CRISPR/Cas9 at endogenous levels. Model was donated by Dr. Zhenyu Yue at Mount Sinai School of Medicine, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:037193
LysoFix-GBA FQ10 (Lysosomal GCase Probe Yellow)*
Assay
This GCase activity probe is a cell-permeable reporter for GCase activity, fluoresces upon glucocerebrosidase activation, facilitating the detection and monitoring of GBA1 activity. These probes were generated and kindly shared through the MJFF Sponsored Tools Program by David Vocadlo.
CTSB Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in CTSB for heterozygous and homozygous knockout. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP).Estimated Availability: Q1 2026
LRRK2 D1994A/G2019S Mouse
Mouse Model
Transgenic mice overexpressing both a mutant form D1994A and G2019S of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene.
Please note: Although founders were positively identified through genotyping and exhibited robust mRNA expression, these projects were halted due to a lack of any appreciable protein expression.
Alpha-Synuclein pS129 Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 129 of alpha-synuclein.
USP30 Knockout A549 Cell Line
Immortalized Cell
A549 cell with homozygous knockout of USP30.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic