To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
-
Sponsored Tools Program
Learn more about how MJFF can help share your tools.
-
Tools Consortium
MJFF is working with industry to develop priority tools.
-
Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
Parkin KO x Polg Mutator Mouse*
Mouse Model
Parkin KO x Polg Mutator mice were generated by crossing PolgAD257A mutant mice, lacking mitochondria polymerase proofreading function, with Parkin KO mice. Model was designed by Kelly Stauch and Howard Fox at University of Nebraska Medical Center and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036670
Ubiquitin pS65 Phosphospecific Antibody (IHC)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine65 of ubiquitin. Suitable for immunohistochemistry applications. Detailed characterization data is published in Watzlawik et al, Autophagy 2024.
Thy-1 Wild Type Human Alpha-Synuclein Mouse (Line 61)*
Mouse Model
Transgenic mice expressing wild type human alpha-synuclein cDNA driven by the mouse Thy1 promoter. Model was developed by Eliezer Masliah and deposited by Robert Rissman at University of California San Diego, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038796
Lentiviral LRRK2 (G2019S)
Viral Vector
Lentiviral vector expressing LRRK2 mutated at residue G2019S. Lentiviral eGFP available as a control in Reporter section.
Please note: This viral vector is not intended for in vivo use.
PDGFβ-Human Alpha Synuclein (Line D) Mouse*
Mouse Model
Mice express wildtype human alpha synuclein cDNA driven by the platelet derived growth factor, β polypeptide (PDGFB) promoter. Model was developed by Eliezer Masliah and deposited by Robert Rissman at University of California San Diego, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038774
Alpha Synuclein Gene Replacement WT (SNCA-GR WT) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039166
Alpha Synuclein Gene Replacement A53T (SNCA-GR*A53T) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039167
Alpha Synuclein Gene Replacement E46K (SNCA-GR*E46K) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the E46K mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039168
Ubiquitin pS65 Phosphospecific Antibody (IHC)
Antibody
Rat anti-pS65 Ubiquitin antibody that has undergone Fc species switching to develop rat reagents from the original rabbit antibody (41H1/41K3). The new chimeric antibody is approved for immunohistochemistry and can be detected using Fc-specific secondary antibodies to rat IgG.
Ubiquitin pS65 Phosphospecific Antibody (WB/ICC/ELISA)
Antibody
Rat anti-pS65 Ubiquitin antibody that has undergone Fc species switching to develop rat reagents from the original rabbit antibody (30H3/30K1). The new chimeric antibody is approved for immunoblotting, immunocytochemistry, and immunoassay, and can be detected using Fc-specific secondary antibodies to rat IgG.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic