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Funded Studies

Christian Johannes Gloeckner, PhD

Group Leader at German Center for Neurodegenerative Diseases (DZNE)

Location: Tubingen Germany

Dr. Christian Johannes Gloeckner studied biochemistry at the University of Hannover and at the Hannover Medical School and obtained his PhD from the Technical University of Munich in 2001. During his doctoral work, Dr. Gloeckner studied protein-protein interactions. As post-doctoral fellow (2001-2004) at LMU Munich, he developed methods to isolate and purify protein complexes associated with inherited diseases using mass spectrometry (specialized technique used to sort chemicals). During that time, he also worked with liquid chromatography tandem--mass spectrometry, another technique that is used to separate and study proteins. Later, at the Helmholtz Zentrum München (2004-2014) and at the University of Tübingen (2010-2014), Dr. Gloeckner studied the functional characterization of Parkinson's disease-associated protein LRRK2. He participated in several studies that evaluated the biochemistry and protein structure of LRRK2, in addition to its associated protein interaction networks and its protein. Based on this work, Dr. Gloeckner reported one of the first demonstrations of LRRK2 kinase activity (2006) and also put forth a structural model of LRRK2 (2016).

Associated Grants

  • Biochemical and Structural Characterization of LRRK2-specific Nanobodies


  • Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease


  • From Structure to Function: Targeting LRRK2-mediated Parkinson's Disease


  • Modelling LRRK2 Structure and Characterizing the LRRK2 Activation Cycle in LRRK2-mediated Parkinson's disease


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