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Funded Studies

Daria Mochly-Rosen, PhD

George D. Smith Professor of Translational Medicine, Senior Associate Dean for Research, and Professor of Chemical and Systems Biology at Stanford University School of Medicine

Location: San Francisco, CA United States

Daria Mochly-Rosen received her BS in life sciences from Tel Aviv University, her PhD from the Weizmann Institute of Science, and was a postdoctoral fellow in the department of biochemistry at University of California, Berkeley. She is a Fellow of the Council on Basic Cardiovascular Sciences of the American Heart Association, a Founding Fellow of the International Society of Heart Research, a member of the NIH Peer Review Advisory Committee and a member of the NIH Council of Councils.

Dr. Mochly-Rosen's research focuses on the rationale design of peptides that interfere with protein-protein interactions to study signal transduction in normal and disease states.  Also, her research encompasses the role of individual protein kinase C isozymes in eukaryotic cell signaling, with current emphasis on the intracellular trafficking of PKC isozymes and modulators of aldehyde dehydrogenase (ALDH) isozymes. Her group has designed peptides that act as specific agonists/antagonists for individual PKC isozymes and small molecules for individiual ALDH isozymes.  These are applied to determine the role of PKC in cardiac hypertrophy and in protection from ischemia-induced cardiac infarction, in stroke, cancer, Parkinson’s Disease and other CNS diseases.

Her research has been funded by the NIH, American Heart Association, California Breast Research Program, American Cancer Society and March of Dimes Birth Defects Foundation.

Associated Grants

  • Aldehyde Dehydrogenase Activators as Novel Drugs For the Treatment of PD


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