Esther Sammler is a clinician scientist at the University of Dundee in the MRC Protein Phosphorylation and Ubiquitylation Unit. She holds a Scottish Senior Clinical Academic Fellowship and her lab is focused on translating basic research findings into the clinical context, working with clinical biosamples and multimodal stratification of patients including genetics, clinical phenotypes and biochemical function with the goal of better understanding Parkinson’s disease (PD). Her particular interest is in LRRK2 kinase signalling in health and disease. As a neurologist, she looks after people with PD and runs clinical trials. Dr. Sammler obtained her medical degree from the Ludwig-Maximillian’s-University in Munich, Germany and worked at the University of Heidelberg before relocating to Scotland. Her received her PhD (Signalling pathway of the E3 ligase subunit FBX07 and its role in hereditary Parkinsonism’ supervised by Professor Dario Alessi) in 2014 and she qualified as consultant neurologist in 2016.
Associated Grants
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From Functional Maps to Clinical Outcomes: Interpreting GBA1 Variant Effects in Parkinson's Disease
2026
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Biomarker Discovery by Interrogating LRRK2 Signaling in Parkinson’s Biosamples with the Asian LRRK2 G2385R and R1628P Variants
2026
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Identifying Biochemical, Histological and Molecular Signatures of Constipation Associated with Parkinson’s Disease
2025
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Establishing a Cohort of Carriers with ATP13A2 Mutations for Clinical and Biomarker Analysis
2024