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Joshua Salafsky, PhD

CSO and Founder at Biodesy, LLC

Location: Burlingame, CA United States

Dr. Joshua Salafsky is the CSO and Founder of Biodesy, LLC and the inventor of the SHG technique for detecting conformational change in biomolecules. Prior to founding Biodesy, he was a postdoctoral fellow in the Dept. of Chemistry at Columbia University and the Dept. of?Physics at Utrecht University in the Netherlands, and a guest researcher at the Cavendish Laboratory at the University of Cambridge. During this time, he invented 'SHG labels'?and the first single-nanocrystal photovoltaic device, a new and highly efficient architecture for photoelectric and solar-cell devices. A nanotechnology company is commercializing the device, while academic groups at Stanford, Berkeley and the University of Tokyo are studying its design and pursuing its full potential. Dr. Salafsky’s?expertise and interests are in the areas of Biophysics and Physical Chemistry. With Biodesy, he and his colleagues are developing SHG into a tool for drug discovery and real time and space measurements of conformational change.  The applications developed at Biodesy all have conformational change as their common theme.  Dr. Salafsky received his PhD from Stanford University where he studied the reaction center protein, the engine at the heart of photosynthesis that converts light into chemical energy.

Associated Grants

  • Development of Potent Conformation-Specific Compounds Directed to Monomeric Alpha-Synuclein


  • Development of modulators of alpha-synuclein conformation for PD therapeutics


  • Development of SHG to Discover Drugs to Selectively Block AlphaS toxicity


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