The work of Luca Scorrano, MD, PhD, has changed classical tenets in the field of apoptosis and mitochondrial pathophysiology. His work on cristae remodeling paved the way for the new field of mitochondrial dynamics. Dr. Scorrano’s lab (i) discovered a molecular staple holding cristae membranes tight, deficient in dominant optic atrophy and targeted during apoptosis; (ii) identified the first molecular bridge between endoplasmic reticulum and mitochondria in a mitochondria-shaping proteins mutated in Charcot-Marie-Tooth IIa; (iii) showed that mitochondria change shape to control autophagy or to produce progesterone during pregnancy; and (iv) demonstrated that respiratory chain supercomplexes depends on cristae shape.