Dr. Michael Henderson is a senior postdoctoral fellow at the Center for Neurodegenerative Disease Research at the University of Pennsylvania. He earned an undergraduate degree from Florida State University, where he studied the regulation of a channel protein that plays a role in brain inflammation. During his PhD studies at Yale University, Dr. Henderson investigated protein folding in the brain and identified the primary pathological aggregate in rare cases of adult-onset neuronal ceroid lipofuscinosis (NCL), a group of inherited neurodegenerative disorders.
His postdoctoral work has focused on understanding the cell-signaling pathways underlying Parkinson’s disease pathogenesis and testing therapeutic molecules in preclinical models. He is now investigating how genetic risk factors can alter the cell-to-cell spread and toxicity of pathological proteins in the brain.