Dr. Huot's lab aims to discover novel pharmacological therapeutics to treat motor and non-motor complications of chronic treatment with levodopa in Parkinson's disease, as well as to find therapies that will slow and, hopefully, reverse Parkinson's disease progression. Dr Huot's lab uses state-of-the-art experimental models of Parkinson's disease to assess the effectiveness of novel drugs. His team employs cutting-edge molecular biology techniques to determine the mechanisms and brain areas underlying the effects drugs acting at new therapeutic targets. To maximize the translational potential of the molecules tested, Dr Huot's team conducts, with a network of collaborators, in vivo brain receptor occupancy and pharmacokinetic studies.