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Richard Jay Smeyne, PhD

Professor and Chair, Department of Neuroscience at Thomas Jefferson University
Location: Philadelphia, PA United States

Dr. Richard Smeyne is Professor and Chair of the Department of Neuroscience at Thomas Jefferson University in Philadelphia as well as the Director of the Jefferson Comprehensive Parkinson’s Disease Center. The Smeyne lab has 3 main research foci:1) how the peripheral immune system interacts with the CNS in the etiology of PD; and how familial PD gene mutations can alter this crosstalk, 2) examining how viruses contribute to the etiology of PD and 3) the role of exercise in slowing the progression of PD.  Dr. Smeyne received his Ph.D. in Neuroanatomy in 1989 from Thomas Jefferson University (Philadelphia, PA), followed by postdoctoral training at the Roche Institute of Molecular Biology (Nutley, NJ) where he pioneered early studies of transgenesis; generating the first inducible transgenic mouse (c-fos-lacZ). Dr. Smeyne has worked in both Pharma (BMS and Hoffmann-LaRoche) and Academia (St. Jude Childen’s Research Hospital and his current position).


Associated Grants

  • Investigating the Role of Immune Cell Exhaustion (ICE) and Biological Immune Aging (BIA) in PD Risk and PD Heterogeneity

    2026


  • Effect of SAR-CoV-2 on Experimental Parkinsonism in a Preclinical Model of Parkinson’s Disease

    2023


  • Immune and Bioenergetic Effects of Alpha-synuclein Preformed Fibril Seeding

    2016


  • GSTpi as a Blood Based Biomarker for Parkinson's Disease

    2011


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