Dr. Vikram Khurana is the division chief for movement disorders and the Tracy T. Batchelor Endowed Chair of Neurology at Brigham and Women’s Hospital and Harvard Medical School. He has made important contributions to understanding alpha-synuclein biology using model systems ranging from yeast to human stem cells, advancing stearoyl co-A desaturase inhibitors to clinical trial and uncovering novel links between to mRNA biology and Parkinson’s disease (PD). His group developed experimental and systems biology approaches to stratify patients with synucleinopathies, work that now drives efforts in precision medicine within the Harvard Biomarkers Study (HBS2.0) and MyTrial Programs that he leads at Mass General Brigham. Recently, the Khurana lab developed “inclusionopathy” models that rapidly develop the advanced pathologies of PD to test therapeutic and radiotracer molecules that bind alpha-synuclein, including those supported for development by The Michael J. Fox Foundation.
Associated Grants
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Defining the Cellular and Molecular Determinants of Variable Genetic Penetrance in Parkinson’s Disease
2020
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