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7281 - 7290 of 8761 Results
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  • Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease
    2022
    Summary Details
    RESTRICTED
    Title: Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease
    Author(s): Danna Jennings, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, Jennifer C. Sasaki, René Meisner, Dolores Diaz, Hilda Solanoy, Xiang Wang, Elvira Negrou, Vitaliy V. Bondar, Rajarshi Ghosh, Michael T. Maloney, Nicholas E. Propson, Yuda Zhu, Romeo Maciuca, Laura Harris, Angela Kay, Peter A. LeWitt, T. Alex King, Drew S. Kern, Aaron Ellenbogen, Ira Goodman, Andrew Siderowf, Jason Aldred, Omid Omidvar, Shababa T. Masoud, Sonnet S. Davis, Annie Arguello, Anthony A. Estrada, Javier de Vicente, Zachary K. Sweeney, Giuseppe Astarita, Marie T. Borin, Bradley K. Wong, Harvey Wong, Hoang N. Nguyen, Kimberly Scearce‐Levie, Carole Ho, Matthew D. Troyer
    Journal Name: Science Translational Medicine
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 14
    Issue #: 648
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1126/scitranslmed.abj2658
    Citation Count: 192
  • Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles
    2022
    Summary Details
    OPEN
    Title: Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles
    Author(s): Anvesh K. R. Dasari, Lucas Dillard, Sujung Yi, Elizabeth Viverette, Alimohammad Hojjatian, Urmi Sengupta, Rakez Kayed, Kenneth A. Taylor, Mario J. Borgnia, Kwang Hun Lim
    Journal Name: Biochemistry
    Publisher: American Chemical Society (ACS)
    Vol: 61
    Issue #: 17
    Start Page: 1766
    End Page: 1773
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1021/acs.biochem.2c00283
    Best OA location URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10289115/pdf/nihms-1906828.pdf
    Citation Count: 9
  • Monitoring gait at home with radio waves in Parkinson’s disease: A marker of severity, progression, and medication response
    2022
    Summary Details
    RESTRICTED
    Title: Monitoring gait at home with radio waves in Parkinson’s disease: A marker of severity, progression, and medication response
    Author(s): Yingcheng Liu, Guo Zhang, Christopher G. Tarolli, Rumen Hristov, Stella Jensen-Roberts, Emma Waddell, Taylor Myers, Meghan Pawlik, Julia Soto, Renée Wilson, Yuzhe Yang, Timothy Nordahl, Karlo J. Lizárraga, Jamie Adams, Ruth B. Schneider, Karl Kieburtz, Terry D. Ellis, E. Ray Dorsey, Dina Katabi
    Journal Name: Science Translational Medicine
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 14
    Issue #: 663
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1126/scitranslmed.adc9669
    Citation Count: 66
  • Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
    2022
    Summary Details
    RESTRICTED
    Title: Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
    Author(s): David A. Candito, Vladimir Simov, Anmol Gulati, Solomon D. Kattar, Ryan Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Günaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul J. Ciaccio, Jennifer Piesvaux, Karin M. Otte, Matthew Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
    Journal Name: Journal of Medicinal Chemistry
    Publisher: American Chemical Society (ACS)
    Vol: 65
    Issue #: 24
    Start Page: 16801
    End Page: 16817
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1021/acs.jmedchem.2c01605
    Citation Count: 17
  • How Prolonged Isolation Affects People With Parkinson Disease During the COVID-19 Pandemic
    2022
    Summary Details
    OPEN
    Title: How Prolonged Isolation Affects People With Parkinson Disease During the COVID-19 Pandemic
    Author(s): Melissa Suran
    Journal Name: JAMA
    Publisher: American Medical Association (AMA)
    Vol: 327
    Issue #: 9
    Start Page: 801
    End Page: 801
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1001/jama.2022.1510
    Best OA location URL: https://jamanetwork.com/journals/jama/articlepdf/2789055/jama_suran_2022_mn_220006_1645750114.50702.pdf
    Citation Count: 6
  • Effect of Urate-Elevating Inosine on Progression of Early Parkinson Disease—Reply
    2022
    Summary Details
    RESTRICTED
    Title: Effect of Urate-Elevating Inosine on Progression of Early Parkinson Disease—Reply
    Author(s): Eric A. Macklin, Alberto Ascherio, Michael A. Schwarzschild
    Journal Name: JAMA
    Publisher: American Medical Association (AMA)
    Vol: 327
    Issue #: 1
    Start Page: 85
    End Page: 85
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1001/jama.2021.21011
    Citation Count: 3
  • Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors
    2022
    Summary Details
    OPEN
    Title: Association of Plasma and Cerebrospinal Fluid Alzheimer Disease Biomarkers With Race and the Role of Genetic Ancestry, Vascular Comorbidities, and Neighborhood Factors
    Author(s): Ihab Hajjar, Zhiyi Yang, Maureen Okafor, Chang Liu, Teresa Waligórska, Felicia C. Goldstein, Leslie M. Shaw
    Journal Name: JAMA Network Open
    Publisher: American Medical Association (AMA)
    Vol: 5
    Issue #: 10
    Start Page: e2235068
    End Page: e2235068
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1001/jamanetworkopen.2022.35068
    Best OA location URL: https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2797044/hajjar_2022_oi_220997_1664303851.08078.pdf
    Citation Count: 50
  • Association of Cerebrospinal Fluid Neurofilament Heavy Protein Levels With Clinical Progression in Patients With Parkinson Disease
    2022
    Summary Details
    OPEN
    Title: Association of Cerebrospinal Fluid Neurofilament Heavy Protein Levels With Clinical Progression in Patients With Parkinson Disease
    Author(s): Linbo Wang, Wei Zhang, Fengtao Liu, Cheng‐Jie Mao, Chun‐Feng Liu, Wei Cheng, Jianfeng Feng
    Journal Name: JAMA Network Open
    Publisher: American Medical Association (AMA)
    Vol: 5
    Issue #: 7
    Start Page: e2223821
    End Page: e2223821
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1001/jamanetworkopen.2022.23821
    Best OA location URL: https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2794635/wang_2022_oi_220672_1659467066.66779.pdf
    Citation Count: 11
  • Effect of Urate-Elevating Inosine on Progression of Early Parkinson Disease
    2022
    Summary Details
    RESTRICTED
    Title: Effect of Urate-Elevating Inosine on Progression of Early Parkinson Disease
    Author(s): Steven J. Frucht
    Journal Name: JAMA
    Publisher: American Medical Association (AMA)
    Vol: 327
    Issue #: 1
    Start Page: 85
    End Page: 85
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1001/jama.2021.21008
    Citation Count: 2
  • Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
    2022
    Summary Details
    OPEN
    Title: Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
    Author(s): Cristina Simonet, Jonathan P. Bestwick, Mark Jitlal, Sheena Waters, Aaron Ben-Joseph, Charles R. Marshall, Ruth Dobson, Soha Marrium, John Robson, Benjamin Meir Jacobs, Daniel Belete, Andrew J. Lees, Gavin Giovannoni, Jack Cuzick, Anette Schrag, Alastair Noyce
    Journal Name: JAMA Neurology
    Publisher: American Medical Association (AMA)
    Vol: 79
    Issue #: 4
    Start Page: 359
    End Page: 359
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1001/jamaneurol.2022.0003
    Best OA location URL: https://jamanetwork.com/journals/jamaneurology/articlepdf/2789505/jamaneurology_simonet_2022_oi_220001_1649435706.38428.pdf
    Citation Count: 64
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