5951 - 6000 of 8399 Results
Title
Year
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OPENTitle: Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive SymptomsJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2018.00441Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2018.00441/pdfCitation Count: 19
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OPENTitle: Prevalence of Parkinson’s disease across North AmericaJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-018-0058-0Best OA location URL: https://www.nature.com/articles/s41531-018-0058-0.pdfCitation Count: 844
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OPENTitle: Determining a Short Form Montreal Cognitive Assessment (s-MoCA) Czech Version: Validity in Mild Cognitive Impairment Parkinson’s Disease and Cross-Cultural ComparisonJournal Name: AssessmentPublisher: SAGE PublicationsVol: 27Issue #: 8Start Page: 1960End Page: 1970Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/1073191118778896Best OA location URL: https://europepmc.org/articles/pmc6274600?pdf=renderCitation Count: 21
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RESTRICTEDTitle: Essential tremor plus is more common than essential tremor: Insights from the reclassification of a cohort of patients with lower limb tremorJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 56Issue #:Start Page: 109End Page: 110Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.06.029Citation Count: 69
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OPENTitle: Longitudinal analysis of impulse control disorders in Parkinson diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 91Issue #: 3Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000005816Best OA location URL: https://europepmc.org/articles/pmc6059034?pdf=renderCitation Count: 215
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OPENTitle: Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human HerpesvirusJournal Name: NeuronPublisher: Elsevier BVVol: 99Issue #: 1Start Page: 64End Page: 82.e7Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.neuron.2018.05.023Best OA location URL: http://www.cell.com/article/S0896627318304215/pdfCitation Count: 624
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OPENTitle: Cognitive Profiles and Hub Vulnerability in Parkinson's DiseaseJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2018.00482Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2018.00482/pdfCitation Count: 42
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RESTRICTEDTitle: Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liabilityJournal Name: Bioorganic & Medicinal Chemistry LettersPublisher: Elsevier BVVol: 28Issue #: 15Start Page: 2641End Page: 2646Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.bmcl.2018.06.034Citation Count: 13
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OPENTitle: Predicting early cognitive decline in newly-diagnosed Parkinson's patients: A practical modelJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 56Issue #:Start Page: 70End Page: 75Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.06.031Best OA location URL: https://europepmc.org/articles/pmc6425482?pdf=renderCitation Count: 27
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OPENTitle: The GBA p.Trp378Gly mutation is a probable French‐Canadian founder mutation causing Gaucher disease and synucleinopathiesJournal Name: Clinical GeneticsPublisher: WileyVol: 94Issue #: 3-4Start Page: 339End Page: 345Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/cge.13405Best OA location URL: https://zenodo.org/record/3911322Citation Count: 10
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RESTRICTEDTitle: Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestriesJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 13Issue #: 6Start Page: e0198166End Page: e0198166Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc0DOI - Digital Object Identifier: 10.1371/journal.pone.0198166Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198166&type=printableCitation Count: 83
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RESTRICTEDTitle: Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug StrategyJournal Name: ACS Chemical NeurosciencePublisher: American Chemical Society (ACS)Vol: 9Issue #: 11Start Page: 2542End Page: 2547Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1021/acschemneuro.8b00236Citation Count: 9
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OPENTitle: Stratification of candidate genes for Parkinson’s disease using weighted protein-protein interaction network analysisJournal Name: BMC GenomicsPublisher: Springer Science and Business Media LLCVol: 19Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1186/s12864-018-4804-9Best OA location URL: https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-018-4804-9.pdfCitation Count: 42
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OPENTitle: Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed ActivationJournal Name: Journal of Alzheimer's DiseasePublisher: SAGE PublicationsVol: 64Issue #: 2Start Page: 597End Page: 606Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jad-180121Best OA location URL: https://europepmc.org/articles/pmc6518401?pdf=renderCitation Count: 91
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OPENTitle: Dual role of USP 30 in controlling basal pexophagy and mitophagyJournal Name: EMBO reportsPublisher: Springer Science and Business Media LLCVol: 19Issue #: 7Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.15252/embr.201745595Best OA location URL: https://doi.org/10.15252/embr.201745595Citation Count: 142
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RESTRICTEDTitle: Tau-targeting therapies for Alzheimer diseaseJournal Name: Nature Reviews NeurologyPublisher: Springer Science and Business Media LLCVol: 14Issue #: 7Start Page: 399End Page: 415Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1038/s41582-018-0013-zBest OA location URL: https://europepmc.org/articles/pmc6463489?pdf=renderCitation Count: 726
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OPENTitle: Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson’s modelsJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 136Issue #: 4Start Page: 607End Page: 620Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-018-1873-4Best OA location URL: https://europepmc.org/articles/pmc6123262?pdf=renderCitation Count: 132
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RESTRICTEDTitle: Consensus for the measurement of the camptocormia angle in the standing patientJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 52Issue #:Start Page: 1End Page: 5Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.06.013Best OA location URL: https://zenodo.org/records/3873641/files/Consensus_Paper.pdfCitation Count: 57
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OPENTitle: A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 56Issue #:Start Page: 27End Page: 32Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.06.001Best OA location URL: http://www.prd-journal.com/article/S1353802018302608/pdfCitation Count: 111
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OPENTitle: Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structureJournal Name: Genome MedicinePublisher: Springer Science and Business Media LLCVol: 10Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13073-018-0551-4Best OA location URL: https://genomemedicine.biomedcentral.com/track/pdf/10.1186/s13073-018-0551-4.pdfCitation Count: 60
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OPENTitle: Movement disorders in non-encephalopathic Hashimoto's thyroiditisJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 55Issue #:Start Page: 141End Page: 142Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.06.008Best OA location URL: https://zenodo.org/records/3873759/files/system_appendPDF_proof_hi.pdfCitation Count: 17
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OPENTitle: Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synucleinJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 117Issue #:Start Page: 170End Page: 180Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2018.05.018Best OA location URL: https://europepmc.org/articles/pmc6051902?pdf=renderCitation Count: 33
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RESTRICTEDTitle: Gene Therapy Strategies to Restore ER Proteostasis in DiseaseJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 26Issue #: 6Start Page: 1404End Page: 1413Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.ymthe.2018.04.004Best OA location URL: https://doi.org/10.1016/j.ymthe.2018.04.004Citation Count: 35
- Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?2018RESTRICTEDTitle: Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?Journal Name: ToxiconPublisher: Elsevier BVVol: 147Issue #:Start Page: 89End Page: 95Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.toxicon.2017.09.004Best OA location URL: https://europepmc.org/articles/pmc5839920?pdf=renderCitation Count: 49
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OPENTitle: Mechanism of parkin activation by PINK1Journal Name: NaturePublisher: Springer Science and Business Media LLCVol: 559Issue #: 7714Start Page: 410End Page: 414Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41586-018-0224-xBest OA location URL: https://europepmc.org/articles/pmc6071873?pdf=renderCitation Count: 326
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RESTRICTEDTitle: mGlu4 allosteric modulation for treating Parkinson's diseaseJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 135Issue #:Start Page: 308End Page: 315Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2018.03.027Citation Count: 27
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RESTRICTEDTitle: The spectrum of “off” in Parkinson's disease: What have we learned over 40 years?Journal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 51Issue #:Start Page: 9End Page: 16Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.02.001Citation Count: 108
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OPENTitle: Immunosuppressants and risk of Parkinson diseaseJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 5Issue #: 7Start Page: 870End Page: 875Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.580Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.580Citation Count: 77
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OPENTitle: LRRK2 activity does not dramatically alter α-synuclein pathology in primary neuronsJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-018-0550-0Best OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0550-0Citation Count: 36
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OPENTitle: Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegenerationJournal Name: SleepPublisher: Oxford University Press (OUP)Vol: 41Issue #: 9Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/sleep/zsy116Best OA location URL: https://academic.oup.com/sleep/article-pdf/41/9/zsy116/25714846/zsy116.pdfCitation Count: 12
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RESTRICTEDTitle: Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson’s Disease and Their First-Degree Unaffected RelativesJournal Name: Brain TopographyPublisher: Springer Science and Business Media LLCVol: 31Issue #: 6Start Page: 1029End Page: 1036Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s10548-018-0653-8Citation Count: 26
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OPENTitle: Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson’s Disease: An In Situ Proximity Ligation Assay StudyJournal Name: International Journal of Molecular SciencesPublisher: MDPI AGVol: 19Issue #: 6Start Page: 1611End Page: 1611Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/ijms19061611Best OA location URL: https://www.mdpi.com/1422-0067/19/6/1611/pdf?version=1527671383Citation Count: 23
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OPENTitle: Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive DeclineJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2018.00394Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2018.00394/pdfCitation Count: 15
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OPENTitle: Increased yield of full GBA sequencing in Ashkenazi Jews with Parkinson's diseaseJournal Name: European Journal of Medical GeneticsPublisher: Elsevier BVVol: 62Issue #: 1Start Page: 65End Page: 69Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.ejmg.2018.05.005Best OA location URL: https://europepmc.org/articles/pmc6261782?pdf=renderCitation Count: 60
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OPENTitle: A novel extended form of alpha-synuclein 3′UTR in the human brainJournal Name: Molecular BrainPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13041-018-0371-xBest OA location URL: https://molecularbrain.biomedcentral.com/track/pdf/10.1186/s13041-018-0371-xCitation Count: 14
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OPENTitle: RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's diseaseJournal Name: Journal of Biological ChemistryPublisher: Elsevier BVVol: 293Issue #: 28Start Page: 11047End Page: 11066Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1074/jbc.ra118.001747Best OA location URL: https://europepmc.org/articles/pmc6052236?pdf=renderCitation Count: 78
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OPENTitle: Patterns and Predictors of Tic Suppressibility in Youth With Tic DisordersJournal Name: Frontiers in PsychiatryPublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fpsyt.2018.00188Best OA location URL: https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00188/pdfCitation Count: 44
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OPENTitle: Separation of Subcutaneous Fat From Muscle in Surface Electrical Impedance Myography Measurements Using Model Component AnalysisJournal Name: IEEE Transactions on Biomedical EngineeringPublisher: Institute of Electrical and Electronics Engineers (IEEE)Vol: 66Issue #: 2Start Page: 354End Page: 364Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1109/tbme.2018.2839977Best OA location URL: https://europepmc.org/articles/pmc6357232?pdf=renderCitation Count: 19
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RESTRICTEDTitle: Determination of Imaging Biomarkers to Decipher Disease Trajectories and Differential Diagnosis of Neurodegenerative Diseases (DIsease TreND)Journal Name: Journal of Neuroscience MethodsPublisher: Elsevier BVVol: 305Issue #:Start Page: 105End Page: 116Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jneumeth.2018.05.009Citation Count: 18
- LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages2018OPENTitle: LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophagesJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 37Issue #: 12Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.15252/embj.201798694Best OA location URL: https://doi.org/10.15252/embj.201798694Citation Count: 164
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OPENTitle: Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicityJournal Name: Archives of ToxicologyPublisher: Springer Science and Business Media LLCVol: 92Issue #: 7Start Page: 2353End Page: 2367Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00204-018-2222-zBest OA location URL: https://link.springer.com/content/pdf/10.1007/s00204-018-2222-z.pdfCitation Count: 19
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OPENTitle: Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s diseaseJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13024-018-0255-7Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-018-0255-7Citation Count: 51
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RESTRICTEDTitle: Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson’s DiseaseJournal Name: Molecular NeurobiologyPublisher: Springer Science and Business Media LLCVol: 56Issue #: 1Start Page: 688End Page: 701Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1007/s12035-018-1109-6Citation Count: 55
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OPENTitle: Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementiaJournal Name: American Journal of Physiology-Heart and Circulatory PhysiologyPublisher: American Physiological SocietyVol: 315Issue #: 2Start Page: H284End Page: H290Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1152/ajpheart.00206.2018Best OA location URL: https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00206.2018Citation Count: 11
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OPENTitle: Somatic copy number gains of α-synuclein (SNCA) in Parkinson’s disease and multiple system atrophy brainsJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 141Issue #: 8Start Page: 2419End Page: 2431Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awy157Best OA location URL: https://academic.oup.com/brain/article-pdf/141/8/2419/25219708/awy157.pdfCitation Count: 68
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RESTRICTEDTitle: Parkinson's disease phenotype is influenced by the severity of the mutations in the GBA geneJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 55Issue #:Start Page: 45End Page: 49Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.05.009Citation Count: 111
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OPENTitle: Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosisJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 55Issue #:Start Page: 92End Page: 96Publication Date:Open Access(OA) Status: OPENLicense: elsevier-specific: oa user licenseDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.05.020Best OA location URL: http://manuscript.elsevier.com/S1353802018302529/pdf/S1353802018302529.pdfCitation Count: 25
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OPENTitle: Testing a longitudinal compensation model in premanifest Huntington’s diseaseJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 141Issue #: 7Start Page: 2156End Page: 2166Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1093/brain/awy122Best OA location URL: https://academic.oup.com/brain/article-pdf/141/7/2156/25094716/awy122.pdfCitation Count: 40
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OPENTitle: Tissue engineered nigrostriatal pathway for treatment of Parkinson's diseaseJournal Name: Journal of Tissue Engineering and Regenerative MedicinePublisher: WileyVol: 12Issue #: 7Start Page: 1702End Page: 1716Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/term.2698Best OA location URL: https://europepmc.org/articles/pmc6416379?pdf=renderCitation Count: 58
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OPENTitle: α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's diseaseJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 37Issue #: 12Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.15252/embj.201798878Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201798878Citation Count: 84