3651 - 3700 of 8620 Results
Title
Year
-
RESTRICTEDTitle: Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PDJournal Name: Journal of Neurology, Neurosurgery & PsychiatryPublisher: BMJVol: 89Issue #: 9Start Page: 989End Page: 994Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1136/jnnp-2018-318060Citation Count: 68
-
OPENTitle: Late‐onset Krabbe disease presenting as spastic paraplegia – implications of GCase and CTSB/DJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 11Issue #: 7Start Page: 1715End Page: 1731Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1002/acn3.52078Best OA location URL: https://doi.org/10.1002/acn3.52078Citation Count: 4
-
OPENTitle: Closing the structure-to-function gap for LRRK2Journal Name: Trends in Biochemical SciencesPublisher: Elsevier BVVol: 47Issue #: 3Start Page: 187End Page: 188Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.tibs.2021.10.003Best OA location URL: http://www.cell.com/article/S0968000421002243/pdfCitation Count: 8
- NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body Myositis2024OPENTitle: NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body MyositisJournal Name: Journal of Cachexia, Sarcopenia and MusclePublisher: WileyVol: 16Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1002/jcsm.13672Best OA location URL: https://doi.org/10.1002/jcsm.13672Citation Count: 5
-
RESTRICTEDTitle: Memory impairment in Parkinson’s disease: The retrieval versus associative deficit hypothesis revisited and reconciled.Journal Name: NeuropsychologyPublisher: American Psychological Association (APA)Vol: 33Issue #: 3Start Page: 391End Page: 405Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1037/neu0000503Citation Count: 30
-
RESTRICTEDTitle: Cell penetrating peptide-mediated transport enables the regulated secretion of accumulated cargoes from mast cellsJournal Name: Journal of Controlled ReleasePublisher: Elsevier BVVol: 202Issue #:Start Page: 108End Page: 117Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jconrel.2015.02.005Citation Count: 19
-
OPENTitle: Rapid 2D 23Na MRI of the calf using a denoising convolutional neural networkJournal Name: Magnetic Resonance ImagingPublisher: Elsevier BVVol: 110Issue #:Start Page: 184End Page: 194Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1016/j.mri.2024.04.027Best OA location URL: https://doi.org/10.1016/j.mri.2024.04.027Citation Count: 2
-
OPENTitle: Longitudinal dysregulation of long non-coding RNAs in Parkinson’s diseaseJournal Name: Experimental Biology and MedicinePublisher: Frontiers Media SAVol: 248Issue #: 20Start Page: 1780End Page: 1784Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1177/15353702231198078Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/10792423Citation Count: 0
-
OPENTitle: Ethnicity and Parkinson’s Disease: Motor and Nonmotor Features and Disease Progression in Latino Patients Living in Rural CaliforniaJournal Name: The Journals of Gerontology: Series APublisher: Oxford University Press (OUP)Vol: 78Issue #: 7Start Page: 1258End Page: 1268Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1093/gerona/glad016Best OA location URL: https://escholarship.org/content/qt8g93b96t/qt8g93b96t.pdfCitation Count: 9
-
OPENTitle: LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosisJournal Name: eLifePublisher: eLife Sciences Publications, LtdVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.7554/elife.51071Best OA location URL: https://doi.org/10.7554/elife.51071Citation Count: 104
-
OPENTitle: White Matter Hyperintensities Related to Parkinson's Disease Executive FunctionJournal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 7Issue #: 6Start Page: 629End Page: 638Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mdc3.12956Best OA location URL: https://movementdisorders.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12956Citation Count: 47
-
RESTRICTEDTitle: Impact of inpatient mobility on outcomes in Parkinson's diseaseJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 135Issue #:Start Page: 107834End Page: 107834Publication Date:Open Access(OA) Status: RESTRICTEDLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.parkreldis.2025.107834Best OA location URL: https://doi.org/10.1016/j.parkreldis.2025.107834Citation Count: 0
-
OPENTitle: Cognitive Performance in Early Neuronal Synuclein Disease with Hyposmia but without Motor Disability: Association with Dopamine Deficiency and Isolated Rapid Eye Movement Sleep Behavior DisorderJournal Name: Annals of NeurologyPublisher: WileyVol: 98Issue #: 3Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1002/ana.27263Citation Count: 0
-
RESTRICTEDTitle: Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neuronsJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 47Issue #: 3Start Page: 367End Page: 377Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2012.05.012Best OA location URL: https://zenodo.org/record/3420973Citation Count: 57
-
OPENTitle: Patient-Centered Identification of Meaningful Regulatory Endpoints for Medical Devices to Treat Parkinson’s DiseaseJournal Name: MDM Policy & PracticePublisher: SAGE PublicationsVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1177/23814683211021380Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1177/23814683211021380Citation Count: 11
-
RESTRICTEDTitle: Progression of clinical markers in prodromal Parkinson’s disease and dementia with Lewy bodies: a multicentre studyJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 146Issue #: 8Start Page: 3258End Page: 3272Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1093/brain/awad072Best OA location URL: https://academic.oup.com/brain/article-pdf/146/8/3258/51018455/awad072.pdfCitation Count: 76
-
OPENTitle: Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disordersJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 10Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-022-01468-8Best OA location URL: https://actaneurocomms.biomedcentral.com/counter/pdf/10.1186/s40478-022-01468-8Citation Count: 58
-
OPENTitle: Sleep, Pain, and Neurodegeneration: A Mendelian Randomization StudyJournal Name: Frontiers in NeurologyPublisher: Frontiers Media SAVol: 13Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fneur.2022.765321Best OA location URL: https://www.frontiersin.org/articles/10.3389/fneur.2022.765321/pdfCitation Count: 18
-
RESTRICTEDTitle: Reaction-Based “Off–On” Fluorescent Probe Enabling Detection of Endogenous Labile Fe2+ and Imaging of Zn2+-induced Fe2+ Flux in Living Cells and Elevated Fe2+ in Ischemic StrokeJournal Name: Bioconjugate ChemistryPublisher: American Chemical Society (ACS)Vol: 27Issue #: 2Start Page: 302End Page: 308Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1021/acs.bioconjchem.5b00259Citation Count: 67
-
OPENTitle: BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron DegenerationJournal Name: NeuronPublisher: Elsevier BVVol: 44Issue #: 6Start Page: 931End Page: 945Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.neuron.2004.11.026Best OA location URL: http://www.cell.com/article/S0896627304007627/pdfCitation Count: 196
-
OPENTitle: Association of Tripartite Motif Containing 11 rs564309 With Tau Pathology in Progressive Supranuclear PalsyJournal Name: Movement DisordersPublisher: WileyVol: 35Issue #: 5Start Page: 890End Page: 894Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.28010Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7528208Citation Count: 9
-
OPENTitle: Ensemblex: an accuracy-weighted ensemble genetic demultiplexing framework for population-scale scRNAseq sample poolingJournal Name: Genome BiologyPublisher: Springer Science and Business Media LLCVol: 26Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13059-025-03643-1Best OA location URL: https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-025-03643-1Citation Count: 0
- Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease2024OPENTitle: Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's DiseaseJournal Name: Annals of NeurologyPublisher: WileyVol: 95Issue #: 6Start Page: 1162End Page: 1172Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/ana.26923Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.26923Citation Count: 9
-
OPENTitle: Detecting and monitoring the symptoms of Parkinson's disease using smartphones: A pilot studyJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 21Issue #: 6Start Page: 650End Page: 653Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2015.02.026Citation Count: 351
-
OPENTitle: Validation of Parkinson's Disease Ascertainment in the Veterans Administration Electronic Medical RecordJournal Name: Movement DisordersPublisher: WileyVol: 40Issue #: 2Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mds.30075Best OA location URL: https://escholarship.org/content/qt27b865zm/qt27b865zm.pdfCitation Count: 2
-
RESTRICTEDTitle: multiplierzv2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry dataJournal Name: PROTEOMICSPublisher: WileyVol: 17Issue #: 15-16Start Page: 1700091End Page: 1700091Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/pmic.201700091Citation Count: 50
-
RESTRICTEDTitle: Clinical phenotype in carriers of intermediate alleles in the huntingtin geneJournal Name: Journal of the Neurological SciencesPublisher: Elsevier BVVol: 402Issue #:Start Page: 57End Page: 61Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jns.2019.05.010Citation Count: 27
-
OPENTitle: Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian AmazonJournal Name: PLOS Neglected Tropical DiseasesPublisher: Public Library of Science (PLoS)Vol: 16Issue #: 11Start Page: e0010773End Page: e0010773Publication Date:Open Access(OA) Status: OPENLicense: cc0, cc0, cc0DOI - Digital Object Identifier: 10.1371/journal.pntd.0010773Best OA location URL: https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010773&type=printableCitation Count: 7
-
OPENTitle: Prevalence and impact of neuropsychiatric symptoms in normal aging and neurodegenerative syndromes: A population‐based study from Latin AmericaJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 19Issue #: 12Start Page: 5730End Page: 5741Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc, cc-by-ncDOI - Digital Object Identifier: 10.1002/alz.13384Best OA location URL: https://escholarship.org/content/qt46w9323v/qt46w9323v.pdfCitation Count: 5
- Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease2018OPENTitle: Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer diseaseJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 137Issue #: 4Start Page: 585End Page: 598Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-018-1947-3Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-018-1947-3.pdfCitation Count: 119
-
OPENTitle: Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFADmice, an animal model of Alzheimer's diseaseJournal Name: Journal of NeurochemistryPublisher: WileyVol: 132Issue #: 2Start Page: 254End Page: 262Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/jnc.12935Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.12935Citation Count: 40
-
OPENTitle: Tet2 loss and enhanced ciliogenesis suppress α-synuclein pathologyJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1186/s40478-025-01988-zBest OA location URL: https://actaneurocomms.biomedcentral.com/counter/pdf/10.1186/s40478-025-01988-zCitation Count: 0
-
OPENTitle: Protein synthesis is suppressed in sporadic and familial Parkinson’s disease by LRRK2Journal Name: The FASEB JournalPublisher: WileyVol: 34Issue #: 11Start Page: 14217End Page: 14233Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1096/fj.202001046rBest OA location URL: https://faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.202001046RCitation Count: 23
-
RESTRICTEDTitle: Vitamin B12 and Homocysteine Levels Predict Different Outcomes in Early Parkinson's DiseaseJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 5Start Page: 762End Page: 770Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.27301Citation Count: 83
-
OPENTitle: Impaired Motor Recycling during Action Selection in Parkinson’s DiseaseJournal Name: eneuroPublisher: Society for NeuroscienceVol: 7Issue #: 2Start Page: ENEURO.0492End Page: 19.2020Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1523/eneuro.0492-19.2020Best OA location URL: https://www.eneuro.org/content/eneuro/7/2/ENEURO.0492-19.2020.full.pdfCitation Count: 2
-
OPENTitle: Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated by α-synucleinJournal Name: Microsystems & NanoengineeringPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41378-020-0147-1Best OA location URL: https://escholarship.org/content/qt6hk8q5kg/qt6hk8q5kg.pdfCitation Count: 10
-
OPENTitle: Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC‐Derived Neural Cells in a Primate Model of Parkinson's DiseaseJournal Name: STEM CELLSPublisher: Oxford University Press (OUP)Vol: 30Issue #: 5Start Page: 935End Page: 945Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/stem.1060Best OA location URL: https://academic.oup.com/stmcls/article-pdf/30/5/935/40773621/stmcls_30_5_935.pdfCitation Count: 166
-
RESTRICTEDTitle: A novel retinal biomarker for Parkinson's disease: Quantifying the foveal pit with optical coherence tomographyJournal Name: Movement DisordersPublisher: WileyVol: 30Issue #: 12Start Page: 1692End Page: 1695Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.26411Citation Count: 23
-
RESTRICTEDTitle: The prodromal phase of leucine‐rich repeat kinase 2–associated Parkinson disease: Clinical and imaging StudiesJournal Name: Movement DisordersPublisher: WileyVol: 32Issue #: 5Start Page: 726End Page: 738Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1002/mds.26964Citation Count: 59
-
OPENTitle: Genomewide Association Studies of LRRK2 Modifiers of Parkinson's DiseaseJournal Name: Annals of NeurologyPublisher: WileyVol: 90Issue #: 1Start Page: 76End Page: 88Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1002/ana.26094Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ana.26094Citation Count: 41
-
RESTRICTEDTitle: Evaluation of Protein Identification and Quantification by the diaPASEF Method on timsTOF SCPJournal Name: Journal of the American Society for Mass SpectrometryPublisher: American Chemical Society (ACS)Vol: 35Issue #: 6Start Page: 1253End Page: 1260Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1021/jasms.4c00067Citation Count: 2
- The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverse2021OPENTitle: The TCR repertoire of α-synuclein-specific T cells in Parkinson’s disease is surprisingly diverseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-020-79726-9Best OA location URL: https://www.nature.com/articles/s41598-020-79726-9.pdfCitation Count: 29
-
RESTRICTEDTitle: Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-PyridonesJournal Name: Organic LettersPublisher: American Chemical Society (ACS)Vol: 21Issue #: 17Start Page: 6946End Page: 6950Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1021/acs.orglett.9b02549Citation Count: 15
-
OPENTitle: Statin Use and Incidence of Parkinson's Disease in Women from the French E3N Cohort StudyJournal Name: Movement DisordersPublisher: WileyVol: 38Issue #: 5Start Page: 854End Page: 865Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/mds.29349Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.29349Citation Count: 14
-
OPENTitle: Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespanJournal Name: PLOS BiologyPublisher: Public Library of Science (PLoS)Vol: 23Issue #: 7Start Page: e3003277End Page: e3003277Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pbio.3003277Best OA location URL: https://doi.org/10.1371/journal.pbio.3003277Citation Count: 0
-
OPENTitle: Brain physiological pulsations are linked to sleep architecture and cognitive performance in older adultsJournal Name: NeuroImagePublisher: Elsevier BVVol: 311Issue #:Start Page: 121187End Page: 121187Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.1016/j.neuroimage.2025.121187Best OA location URL: https://doi.org/10.1016/j.neuroimage.2025.121187Citation Count: 0
-
OPENTitle: Synchronous Measurements of Extracellular Action Potentials and Neurochemical Activity with Carbon Fiber Electrodes in Nonhuman PrimatesJournal Name: eneuroPublisher: Society for NeuroscienceVol: 11Issue #: 7Start Page: ENEURO.0001End Page: 24.2024Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-sa, cc-byDOI - Digital Object Identifier: 10.1523/eneuro.0001-24.2024Best OA location URL: https://doi.org/10.1523/eneuro.0001-24.2024Citation Count: 4
-
OPENTitle: Sleep disorders and mortality: A prospective study in the Canadian longitudinal study on agingJournal Name: Sleep MedicinePublisher: Elsevier BVVol: 114Issue #:Start Page: 128End Page: 136Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.sleep.2023.12.023Citation Count: 4
-
OPENTitle: Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiencyJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol: 33Issue #: 10Start Page: 860End Page: 871Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1093/hmg/ddae018Best OA location URL: https://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddae018/56612521/ddae018.pdfCitation Count: 2
-
OPENTitle: Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in miceJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 35Issue #: 18Start Page: 2008End Page: 2025Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.15252/embj.201593585Best OA location URL: http://doi.org/10.15252/embj.201593585Citation Count: 64