… implicated in Parkinson's pathology to date indicates that multiple physiological routes can lead to PD, and these … the disease." A Holistic Approach Parkinson's arises from multiple, complicated gene-environment interactions on the …

… allow data to be compared across patient cohorts. “It takes multiple cohorts and multiple discoveries to verify particularmarkers,” Frasier …

… (OCT) imaging. OCT is a real-time optical imaging system that produces high-resolution images of the brain. It … Outcome:  The most important outcome will be to provide a system that gives real time intraoperative feedback on … research team has integrated the OCT probe with a delivery system that allows the delivery of viral vectors to targets …

… that side effects (if any) of such treatment on the immune system can be avoided. The role of wild-type and mutant … inhibitors on immune cell function, will be tested in model systems. Hypothesis: Due to the increased enzymatic activity … manifest itself in changes in the ability of the immune system to respond to infection. We further hypothesize that …

… of dyskinesias is based on our studies, which show that nicotine reduces levodopa-induced abnormal involuntary … evaluate the antidyskinetic potential of nicotinic drugs. Nicotine most likely exerts its effects by interacting with nAChRs. However, nicotine activates all nAChRs in the peripheral and central …

… is pointing to the fact that Parkinson’s may involve other systems in the body, beyond the central nervous system. “I am amazed to think how our vision of PD continues … the entire brain itself to include the colon and other systems. We should have no fear to change our perspectives …