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Targeting Dramatically Activated Astrocytic Networks for Managing LID: a Target Validation Program
… their role in Parkinson’s disease and levodopa- induced dyskinesia pathological changes has remained almost … in new pathophysiological and therapeutic directions. … Dyskinesia … Clinical Trial … Alabama … United States … …
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Role of the Ras/ERK signaling pathway in the development of dyskinesia and motor fluctuationsduring chronic L-DOPA treatment
… Such effects include, abnormal involuntary movements (dyskinesia) and fluctuations in motor function. The … both of which have been implicated in the genesis of dyskinesia. In this project, the levels of activation of …
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The Role of Serotonergic and Dopaminergic Mechanisms and their Interaction in L-DOPA Induced Dyskinesias
… play a crucial role in the development of L-dopa induced-dyskinesia. However, this process is likely to be just a … entitled “Serotonergic mediated peak-dose L-DOPA-induced dyskinesias in Parkinson’s disease” was accepted for …
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Gene Expression Changes in Striatal Cholinergic Interneurons Associated with Levodopa-induced Dyskinesia
… part of the brain called the striatum in levodopa-induced dyskinesia. This small population of striatal neurons has … for PD. We will carry out a similar approach for PD and dyskinesia models. Hypothesis: We hypothesize that selective …
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The role of serotonin neurons in the induction and maintenance of dyskinesias in grafted and L-DOPA-primed animals
… the cause of debilitating involuntary movements, so-called dyskinesias. The effects of levodopa, both positive and …
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Pre-clinical characterization of 5-HT1A/1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
… progresses, debilitating involuntary movements, so-called dyskinesias. The serotonin neurons are known to be able to …