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Study of Dyskinesia Treatment Enrolls First Patient
November 11, 2013
… A study testing a new drug to treat levodopa-induced dyskinesia has enrolled its first patient. Avanir … AVP-923 to a placebo to test its efficacy in relieving dyskinesia, involuntary movements associated with long-term … a two-hour levodopa infusion to test the drug effect on dyskinesia. Patients will be carefully monitored throughout …
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Optimization of Selective Mu Opioid Receptor Antagonists for the Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease
… Receptor Antagonists for the Treatment of Levodopa-Induced Dyskinesias in Parkinson's Disease Promising Outcomes of … in a pre-clinical model for reduction of levodopa-induced dyskinesia. ADC5510 has an inverted U-shape dose-response … with respect to the reduction in levodopa-induced dyskinesia and the reason for the shape of the dose-response …
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Preclinical Evaluation of a 5-HT2A Antagonist for Treatment of L-DOPA-Induced Dyskinesias in Parkinson's Disease
… with the appearance of abnormal motor movements called dyskinesias. Medications effective in reducing the incidence and severity of dyskinesias induced by chronic levodopa treatment are … compounds for their ability to ameliorate levodopa-induced dyskinesias in a well-characterized animal model of PD. …
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Breaking News: New Dyskinesia Drug Submitted to FDA
October 31, 2016
… A new drug for levodopa-induced dyskinesia -- involuntary, uncontrolled movements that can … levels are meant to peak during the day, when control of dyskinesia is needed most, and decrease at night, when … be the first specifically indicated for levodopa-induced dyskinesia. (A shorter-acting form of amantadine often is …
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The Parkinson's Minute: A Promising Target to Treat Dyskinesia
June 13, 2012
… person with Parkinson’s disease (PD) who is struggling with dyskinesia, the often uncontrollable movements that are a … side effect of PD drugs. “I just can’t wait for a cure for dyskinesia, if not Parkinson’s,” she says. Dyskinesia is a real burden for many with PD. Bill Langston, …
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The Role of Serotonin Neurons in the Induction of Dyskinesia in Grafted and L-DOPA-primed Animals
… of serotonin neurons in the induction and maintenance of dyskinesias in grafted and L-DOPA-primed animals Levodopa, … the cause of debilitating involuntary movements, so-called dyskinesias. The effects of levodopa, both positive and … The role of seratonin neurons is in the development of dyskinesias is particularly interesting since they not only …