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Fyn knockdown prevents levodopa-induced dyskinesia in a mouse model of Parkinson's disease
June 7, 2021
… often develop side effects, known as levodopa-induced dyskinesia (LID), that usually need therapeutic … exposure to assess its ability to prevent or revert dyskinesia. Pre-administration of miRNA-Fyn reduced LID with …
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Addex Moving Forward with Phase II Study to Reduce Levodopa-induced Dyskinesia
September 27, 2011
… dipraglurant (ADX48621), in reducing levodopa-induced dyskinesia in patients with Parkinson’s disease (PD). The … blocking the action of mGluR5 prevented levodopa-induced dyskinesias in pre-clinical models of PD. MJFF research …
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Trial Testing Dyskinesia Drug Moves Forward with Support from Global Parkinson’s Organizations
November 23, 2020
… “Dyskinesia is absolutely the worst part of having … out with my kids and people stare or make awful remarks.” Dyskinesia is involuntary, irregular movement that can occur …
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The Michael J. Fox Foundation Commits $2 Million to New Dyskinesias Research Program
February 7, 2003
… committed $2 million to a new research intiative to study dyskinesias, the involuntary, uncontrollable movements that …
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Anatomical and neurochemical characterization of basal ganglia neuropeptides in levodopainduceddyskinesia
… such as abnormal involuntary movements (levodopa-induced dyskinesia) develop in many patients. It is still not known … called neuropeptides may be an important step in producing dyskinesias. This project will study the production of these …
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Support for your Collaboration on Proof-of-concept clinical trial on the use of the 5-HT1A/1B Partial Agonist Eltoprazine for Treatment of L-DOPA-induced Dyskinesias. - Linked to Bjorklund CIA 2009
… in the brain -- for alleviation of involuntary movements, dyskinesia, a side-effect of levodopa. Project Description: … drug Eltoprazine. The Lund team has shown that the abnormal dyskinesia-inducing dopamine release can be effectively …