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Inhaled Levodopa as a Treatment for Intermittent Motor Fluctuations in Parkinson’s Disease
… and durable improvement in motor function without worsening dyskinesia in Parkinson’s patients. Results from prior … in OFF time without an increase in time ON with dyskinesia were recorded by patients. CVT-301 was generally …
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Testing Effects of Improved Levodopa Delivery with Dexterity and Gait Objective Measures
… of levodopa should result in a reduction of side effects (dyskinesia: uncontrolled movements when levels are too high) … disease symptoms should have an added benefit of reducing dyskinesia and akinesia that are caused by current levodopa …
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Preferential Targeting of Subpopulations of 5-HT1A Receptors
… a receptor) are capable of reducing levodopa-induced dyskinesias. However, current 5-HT1A agonists are poorly …
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Development of an mGluR5 Imaging Marker for Parkinson's Disease
… in the brain may be important in the development of dyskinesias in PD. Project Description : Six PD subjects …
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Testing PDE-1 Inhibitor in MPTP-treated Macaques
… actions of low-dose levodopa therapy and reduce adverse dyskinesias. To this end, we tested a small-molecule … for its ability to reverse akinesia and attenuate motor dyskinesias in a rodent model of PD. PD models treated with …
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Testing PDE-1 Inhibitor in MPTP-treated Macaques
… actions of low-dose levodopa therapy and reduce adverse dyskinesias. To this end, we tested a small-molecule … for its ability to reverse akinesia and attenuate motor dyskinesias in a pre-clinical model of PD. This model …