… from a prior grant: Role of LRRK2 in Levodopa-induced Dyskinesia Promising Outcomes of Original Grant: … development of drug-induced involuntary movements called dyskinesia. We initially hypothesized that increased LRRK2 activity could worsen dyskinesia, but results from our pre-clinical study showed …

… Study Rationale: Levodopa frequently induces dyskinesia, an abnormal involuntary movement. In our … Fyn could be responsible in part for the development of dyskinesia. Fyn is a substance present inside nerve cells … information between nerve cells is involved in the cause of dyskinesia. Our idea is that Fyn is modified by the …

… Levodopa-induced dyskinesia (LID) is a major source of disability of many … a 10-day course of low frequency rTMS of the motor cortex. Dyskinesia will be assessed by the response to a dose of … therapies for PD patients. … Complications of Treatment … Dyskinesia … Deep Brain Stimulation … Clinical Trial … …

… as on-off fluctuations and involuntary movements called dyskinesias. Recent work in specialized clinics have shown … strategy, not only as a strategy to prevent or reverse dyskinesias associated with standard systemic medication but … patients quality of life. … Complications of Treatment … Dyskinesia … Gene Therapy … Sweden … Academia/Nonprofit … …

… role in the neural mechanisms underlying levodopa-induced dyskinesia (LID). Gap junctions are a special type of … been no studies on the role of GJC in the generation of dyskinesia in well-validated animal models of LID. The … abnormalities of GJC and the role they play in generating dyskinesia in both rodent and the MPTP-lesioned primate …

… L-DOPA-induced dyskinesia (abnormal involuntary movements, AIMs) is a major … Parkinson's disease. Subjects suffering from L-DOPA-induced dyskinesia show complex cellular changes in the brain region … cellular changes. However, a valid model of L-DOPA-induced dyskinesia in the mouse has thus far not been available. In …