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The Role of Abnormal Gap Junction Communication in the Generation of Levodopa-induced Dyskinesia in Parkinson's Disease
… role in the neural mechanisms underlying levodopa-induced dyskinesia (LID). Gap junctions are a special type of … been no studies on the role of GJC in the generation of dyskinesia in well-validated animal models of LID. The …
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Role of Kinase Fyn in Levodopa-induced Dyskinesia
… Study Rationale: Levodopa frequently induces dyskinesia, an abnormal involuntary movement. In our … Fyn could be responsible in part for the development of dyskinesia. Fyn is a substance present inside nerve cells …
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LRRK2 Activity and Dyskinesia
… from a prior grant: Role of LRRK2 in Levodopa-induced Dyskinesia Promising Outcomes of Original Grant: … ¬-- the main target of dopamine in the brain -- increased dyskinesias in pre-clinical models of Parkinson's. This …
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LRRK2 Activity and Dyskinesia Supplement
… upon the research from a prior grant: LRRK2 Activity and Dyskinesia Promising Outcomes of Original Grant: Our … of striatal LRRK2 in the development of levodopa-induced dyskinesia (LID). We found that inhibiting LRRK2 in the …
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Reversal of Dyskinesias By in-vivo Gene Transfer of L-DOPA Using Adeno-associated Viral Vectors
… as on-off fluctuations and involuntary movements called dyskinesias. Recent work in specialized clinics have shown …
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Dyskinesia & Abnormal Regulation of DARPP-32
… L-DOPA-induced dyskinesia (abnormal involuntary movements, AIMs) is a major … Parkinson's disease. Subjects suffering from L-DOPA-induced dyskinesia show complex cellular changes in the brain region …