… study will use the analysis of electrical activity recorded from hand muscles during handwriting and at rest. There will … muscles, was able to significantly discriminate PD subjects from controls during a writing exercise. Our study was able … seems to behave as a good marker for levodopa efficacy (from OFF to ON state). This methodology has potential to be …

… sebum. Pre-clinical models will be exposed to sebum samples from individuals with PD and age-matched controls. Following … gene expression analysis using olfactory tissue from both groups and will define a list of candidate … for early-stage PD diagnostics. By extracting sensors from PD MouSensors, we may eventually create a …

… vesicular trafficking. For this purpose, we will use cells from individuals with PD who carry LRRK2 mutations and cells from LRRK2 pre-clinical models. The latter types of cells … may contribute to the establishment of tests using samples from individuals with PD, enabling determination of target …

… Our aim is to demonstrate that the OM, collected from individuals at early stages of dementia, contains … FTD-tau. Study Design: Olfactory mucosa samples, collected from a well-characterized group of individuals with AD, LBD … and Alzheimer's disease. Such impairment might arise from the accumulation of disease-related proteins in the OM. …

… Study Rationale: Parkinson's disease (PD) research benefits from knowledge of disease-specific risk and resilience … tract as well as the nasal cavity accompany PD from its onset and progression. We specifically hypothesize … metabolic signatures in feces and/or nasal lavages from an existing PD cohort, (ii) Validation of the biomarker …

… This grant builds upon the research from a prior grant: Structural Insights into Activated … we examined how Parkin changes its conformation as it goes from an inactive form to the active form. We were able to … inside cells behaves as it does in our model as it moves from an inactive to an active form. Study Design: We have …