… optimization, approximately 100,000 compounds selected from the BioFocus libraries were screened in both assay formats at a single concentration of 10 micromolar. From the Thioflavin T screen, approximately 2,000 compounds …

… accessible biomarkers — objective measures of disease — from biofluids (blood, urine, saliva or cerebrospinal fluid) … analyze regular and phosphorylated proteins in biosamples from people with PD using our EVtrap technology for quick and efficient capture of EVs from urine. We will analyze 106 urine samples available …

… to combine efforts, and together we have collected DNA from thousands of people with Parkinson’s disease and … and analyze the East Asian data using the methods optimized from previous IPDGC genome-wide association (European) … we will further increase our cohort size as experiences from the IPDGC suggest novel findings occur up until tens of …

… About In September 2019, the U.S. Food and Drug Administration (FDA) approved Myobloc for chronic … years with disease. Drooling not only can be embarrassing and socially limiting, it also can lead to skin irritation. … botulism ( an infectious illness that causes weakness) and is injected into the glands that make saliva to …

… will use extensive tissue arrays of different brain regions from patients at different stages of PD. This will allow the … analyzing different astroglia types affected by or spared from alpha-synuclein pathology in the different brain … compared to those of other species, making direct proof from post-mortem human brains irreplaceable when seeking …

… Study Design: We will capture neuronal exosomes from the serum of people at risk of developing Parkinson’s … nerve cells. We will also study nerve cells generated from the individuals’ stem cells to determine whether the … needed to identify those individuals most likely to benefit from therapies that aim to stop or slow down Parkinson’s …