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Use of Neuronal Exosomes to Predict Parkinson’s Disease
… Study Design: We will capture neuronal exosomes from the serum of people at risk of developing Parkinson’s … nerve cells. We will also study nerve cells generated from the individuals’ stem cells to determine whether the … needed to identify those individuals most likely to benefit from therapies that aim to stop or slow down Parkinson’s …
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Potential Therapy Targeting Key Parkinson’s Protein Advances in Human Trials
May 18, 2021
… alpha-synuclein. “Developing treatments to protect cells from alpha-synuclein toxicity is a priority goal for the … In September 2020, Prothena and Roche announced results from their Phase II trial ( the PASADENA trial ). While the … our regular Research Roundup blog posts. ( Read the latest from March. ) Another study is helping better understand and …
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Pesticide Exposure, Systems Biology and Parkinson’s Disease
… : We hypothesize that chronic, low-level pesticide exposure from living or working near agricultural farms may be … application. The CA-PUR database has information from 1974 to 2018 on 200+ pesticides. We will apply a … and metabolome) to a large, population-based study of PD from the California Central Valley (n=1,870), with …
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Modulation of Epigenetic Regulator HDAC4 as a Parkinson’s Treatment
… Study Rationale: Scientists can take skin cells from people with Parkinson’s disease (PD), turn them into … of PD cellular pathology in stem cell-derived neurons from PD patients carrying mutations in the LRRK2 , GBA or … we will look for HDAC4 misplacement in human brain tissue from control volunteers and PD patients. Impact on …
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Exploring the Role of FAIM, an Inhibitor of Cell Death, in Parkinson’s Disease
… discovered that a protein called FAIM can protect neurons from stress-induced death by preventing or reversing the … engineering technology, we will generate neurons derived from the cells of people with mutations in SNCA , the gene … PD models and dopamine-producing neurons derived from people with PD. … Alpha-Synuclein … Target Advancement …
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Mapping the Modulatory Landscape Governing Striatal Dopamine Signaling and Its Dysregulation in Parkinson’s Disease
… long and thin fibers called axons that release dopamine from thousands of different points, sending signals to other … cooperation between striatum and the release of dopamine from axons, then we could provide new knowledge toward ways … molecules in mice that develop Parkinson’s and in cells from people with Parkinson’s, to then suggest new ways that …