… proteome chip with 4200 human proteins purified from a yeast expression system. We will then confirm the … We anticipate that we will indentify LRRK2 substrate(s) from protein arrays and post confirmation experiments. If we …

… heat shock protein 70, a molecule known to protect neurons from the toxic effects of alpha-synuclein in animal models … therapeutic may prevent debilitating symptoms of PD from ever appearing. Final Outcome It proved difficult to …

… they can block toxicity of the oligomers and clear them from the cell. A major advantage of targeting only the toxic … of alpha-synuclein provided partial or full protection from toxicity due to intracellular overexpression of …

… your speech slurred or softer? Do you have trouble rising from a chair? Do your lips, hands, arms and/or legs shake? … start a conversation. Print this page Used with permission from the following publication: York MK, Benge JF, Hunter C, …

… antibodies in animals as well as humans. This is different from most other platforms where strong adjuvants not … resulting in failure to translate these observations from models to clinical efficacy in humans. We expect that …

… human diseases.  “Streamlining the drug discovery process from the lab to the pharmacy shelf has been a key focus of … gain insight into other diseases while applying learnings from our experience in Parkinson’s — all to help propel the …