… for editing genes and for producing neurons derived from the cells of individuals with PD, we propose to study … six lesser-studied PD genes in human neurons derived from the cells of people with PD. We will determine whether …

… tools, researchers can derive insightful measurements from such images. However, measurements provided by … new methods to reconcile disparate measures obtained from different types of image analyses, resulting in more …

… modifications in brain tissue extracts and biofluids from people with early and more advanced PD versus healthy … brain samples, cerebrospinal fluid, blood samples from healthy controls and individuals with PD, DLB and MSA. …

… whether individuals who develop clinical symptoms differ from those who remain healthy despite carrying the same … define specific markers that protect some mutation carriers from having clinical symptoms and to identify …

… cognitive tests for people with PD who have been followed from disease onset out to 7 years. We will combine the … this composite score can differentiate people with PD from healthy controls, and whether it can be used to predict …

… communicate with their doctor and receive DBS adjustments from home or another location with WiFi or cellular access. … extend beyond our current situation, to people who live far from their clinician or who have symptoms that make travel …