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Dissecting the Role of GBA1 and LRRK2 in Regulating the Formation of Lewy Bodies
… of pathology development, most likely during the transition from alpha-synuclein aggregation to Lewy body-like … Study Design: We will carry out these studies using neurons from mice that have PD-linked mutations in the LRRK2 and …
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Protective Effect of Immune Gene Subtype in Parkinson’s Disease
… and why individuals with the HLA-DRB1*04 gene are protected from PD. The findings could lead to new immune-based … and compare the alpha-synuclein reactive immune T cells from PD patients and controls. Impact on Diagnosis/Treatment …
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Using Small Molecules that Modulate Mitochondrial Function for the Treatment of Parkinson's Disease
… or reversal of pathologies seen in cells and neurons from people with PD, providing a potential disease-modifying … to improve mitochondrial function in cells and neurons from people with PD or in cells that replicate the deficits …
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Leveraging Gene Expression Data to Redefine Parkinson’s Disease and the Pathways Driving Disease in Different Individuals
… stages of the disease. Study Design: We will use data from the Parkinson’s Progression Marker Initiative to study blood RNA profiles generated from individuals with PD over time. Using RNA-sequencing …
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Using a Virally Encoded, Single-chain Antibody as a Noninvasive Gene Therapy for Parkinson’s Disease
… Antibodies Blocking Alpha-synuclein Toxicity and Spread for the Treatment of Parkinson’s Disease Study Rationale: … cells. Study Design: We will expose cohorts of mice to preformed alpha-synuclein fibrils and then inject the animals … viruses are also effective on human brain cells. Next Steps for Development: If successful, our approach should pave the …
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Sohini Chowdhury
… several in-house projects. Sohini graduated with an MA from Georgetown University and holds a BA in International Studies from Vassar College. …