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Determining the Ligase and DUB Landscape of Mitochondrial and Alpha-synuclein Turnover
… of Parkinson’s disease. Enhancing the removal of these from the brain would likely help treat the disease. In … deplete all the different ubiquitin ligases and DUBs from cells (over 600 enzymes). They will look to see how …
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Cellular Mechanism of LRRK2 in Health and Disease
… inside cells. We will test additional ideas that arise from the experiments we perform. Study Design: Our … of LRRK2 and test emergent cellular hypotheses resulting from this work, including whether LRRK2 regulates the …
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Bringing Parkinson’s Policy Priorities to the New Congress
January 25, 2021
… for the 117th Congress. This new Congress has a full agenda from the start — from COVID-19 to fulfilling campaign promises and confirming …
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Discovery of Selective PET Imaging Agents for Tauopathies and Alpha-Synuclein
… This grant builds upon the research from a prior grant: Alpha-synuclein/Tau Imaging Consortium … are effective in removing excess alpha-synuclein and tau from the brain is essential to assist effective drug …
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Harnessing the ADAR Protein to Repair the LRRK2 Mutation Causing Parkinson's Disease
… cells. The top candidates will be tested in cells derived from people with PD, where we will assess whether these ASOs … of our approach in pre-clinical models and in cells derived from people with PD, we will move the resulting ASOs into …
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Development of Standardized Measurements for Monitoring the Progression of Parkinson’s Disease via MRI
… set of standardized brain measurements that can be obtained from an MRI scan easily and automatically. These … We will make use of existing clinical and MRI datasets from individuals with PD who have participated in a variety …