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The Role of Serotonergic and Dopaminergic Mechanisms and their Interaction in L-DOPA Induced Dyskinesias
… of involuntary movements and compare the data with those from healthy subjects and PD patients who do not suffer from this side-effect. For this purpose we intend to make …
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Characterization of NPT001-mediated Alpha-Synuclein Disaggregation and Clearance
… disrupts and clears a variety of amyloid aggregates from the brain. In addition to reducing amyloid-beta and tau … will be effective in clearing alpha-synuclein deposits from the brains of transgenic pre-clinical models. It is …
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The Polo Like Kinases (PLK2 and PLK3) as Therapeutic Targets for Parkinson's Disease
… involved in regulating its phosphorylation in vivo. Studies from our laboratory demonstrate point to PLK2 and PLK3 as … phosphorylation. By comparing the results obtained from overexpressing both the wild type and kinase-dead …
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Is the Xenomitochondrial Pre-clinical model an ‘Ideal’ Parkinson’s Disease Model?
… altered mitochondrial genome. This small genome, inherited from our mothers, codes for a few important proteins … defects. Anticipated Outcome: We expect to learn from this project whether our novel pre-clinical model holds …
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Analysis of the ENS Using Routine Colonic Biopsies as a Biomarker for PD: Optimizing Detection of Alpha-Synuclein Pathology and Assessment in LRRK2 Patients
… This grant builds upon the research from a prior grant: Analysis of the Enteric Nervous System … is due to a concomitant involvement of susceptible neurons from peripheral and central nervous systems. …
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Behind the Scenes of Zack Grant's Documentary, "Shake With Me"
March 26, 2019
… had never expressed to me outside the context of the film. From there, I embraced the personal nature of this project. … for whatever the future holds. Watch "Shake With Me" from Zack Grant on Vimeo . For more information on the …