The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 37)
LRRK2 Biology Consortium, 2017
Promising Outcomes of Original Grant:
Our original project investigated how the LRRK2 mutation, the principal genetic cause of Parkinson's disease (PD), alters brain activity involved in movement control and sleep quality. In line with our original hypothesis, we observed that pre-clinical models with the LRRK2 mutation slept less and had more powerful sleep spindles, a form of brain wave involved ...
Researchers: Stephen L. Cowen, PhD
Research Grant, 2016
Chronic Effects of Low Frequency Deep Brain Stimulation on Aspiration, Freezing of Gait and Other Axial and Motor Symptoms in Parkinson's Disease
Our recent study (Xie et al., Neurology. 2015;84:415-420) found that 60Hz stimulation, compared to the traditional 130Hz, decreased aspiration frequency and swallowing difficulty, medication refractory freezing of gait (FOG), and other axial symptoms and parkinsonism in those with Parkinson's disease (PD) following bilateral subthalamic nuclei (brain regions associated with PD; STN...
Researchers: Tao Xie, MD, PhD
Therapeutic Pipeline Program, 2016
Anxiety disorders occur in up to 35 percent of people with Parkinson's disease and can have a negative impact on gait, involuntary movements, motor fluctuations and quality of life. With this study we intend to develop a treatment module for anxiety in patients with Parkinson's disease based on cognitive behavioral therapy methods and assess its efficacy in reducing anxiety symptom...
Researchers: Albert F. G. Leentjens, MD, PhD
Therapeutic Pipeline Program, 2015
Gait and balance disorders are the primary motor disability in advanced Parkinson's disease (PD). These disorders arise in part due to dysfunction of the lateral mesencephalus [part of the brainstem] and one of its nuclei, the pedunculopontine nucleus (PPN). Deep brain stimulation (DBS) of the PPN area has been used to alleviate gait disorders, and while the init...
Rapid Response Innovation Awards, 2014
Neurodegeneration has proven notoriously difficult to study. The main barrier to progress has been the challenging, heterogeneous nature of brain tissue. Optogenetics is a neuromodulation method that allows fast and specific bidirectional control of defined brain circuits in intact systems.
We will use technical expertise with optogenetics to test the effi...
Researchers: Viviana Gradinaru, PhD