The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 17)
Research Grant, 2018
The PINK1 and parkin proteins jointly ensure quality control of mitochondria, the cell's powerhouse. Together they modify damaged mitochondria with phosphorylated ubiquitin (pS65-Ub), which appears to label the mitochondria for degradation. In some genetic forms of Parkinson's, PINK1 and parkin activity is lost, and mitochondrial dysfunction is seen in the broader Parkinson's popul...
Researchers: Wolfdieter Springer, PhD
Therapeutic Pipeline Program, 2017
The Parkin protein (encoded by the PARK2 gene that is linked to Parkinson's), has been shown to exert potent neuroprotective effects that could potentially be used to treat Parkinson's disease (PD). Cellivery has developed a recombinant cell-permeable Parkin protein (iCP-Parkin) using macromolecule intracellular transduction technology (MITT), a technique that can deliver active Pa...
Research Grant, 2017
Promising Outcomes of Original Grant:
Mitophagy is a cellular process during which damaged mitochondria, or energy generators, are broken down. Mitophagy has been suspected to malfunction in Parkinson's disease (PD), but evidence to support this does not exist. Using our new pre-clinical model, we have proven that mitophagy does take place in healthy brain cells but does not require a series of che...
Researchers: Ian G. Ganley, PhD
Research Grant, 2017
The protein Parkin prevents cell death by breaking down damaged mitochondria, cells' energy generators. Mutations in the Parkin gene -- genetic changes that render the protein unable to perform its function -- can lead to loss of neurons and contribute to Parkinson's disease (PD). We created cells with mutations that do just the opposite, making Parkin more active. While some of t...
Researchers: Jean-François Trempe, PhD
Target Advancement Program, 2016
Failure in the quality control of mitochondria (power houses of the cell) in neurons may contribute to Parkinson's disease (PD). Parkin is an enzyme that tags proteins from damaged mitochondria with ubiquitin (a small protein) to promote their degradation (break down). Mutations in Parkin contribute to some forms of PD. Parkin adopts an inactive conformation (structure) in the con...
Researchers: Kalle Gehring, PhD