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The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Access to Data and Biospecimens, 2020Association of Repetitive DNA Elements in Parkinson’s Disease Risk and Progression
Study Rationale:
Repetitive DNA elements such as “jumping genes” were previously considered ‘junk DNA’. However, it is now known that these elements are involved in the development of several diseases... -
Research Grant, 2019Long-acting GM-CSF Fusion Protein (PDM608) for the Treatment of Parkinson’s Disease
Study Rationale:
Emerging evidence suggests that the modulating the peripheral immune system can be a powerful disease-modifying approach for the treatment of Parkinson's disease (PD). We have... -
Therapeutic Pipeline Program, 2019Oligomeric Alpha-synuclein-specific Antibody-based Gene Therapy
Study Rationale:
Alpha-synuclein is the primary component of Lewy bodies, the hallmark of Parkinson’s disease (PD). In particular, soluble aggregates of alpha-synuclein, also referred to as oligomers,... -
Astrocyte Biology in Parkinson's Disease, 2019Astrocyte Gene Expression in Parkinson’s Interrogated Using Single Cell Nuclear RNA Sequencing
Study Rationale:
Astrocytes are one of the major non-neuron cell types in the brain and control many neurological processes. They are likely to be changed in Parkinson’s disease (PD) and may... -
Astrocyte Biology in Parkinson's Disease, 2019Characterization of Astrocytes in Aging and Lewy Body Pathology
Study Rationale:
Astrocytes are brain cells with crucial roles, including communication between nerve cells, clearance of unwanted material, and response to injury. It has been suggested that astrocyte... -
Astrocyte Biology in Parkinson's Disease, 2019Control of Astrocyte Function by LRRK2
Study Rationale:
Mutations in the LRRK2 gene are known to cause Parkinson’s disease (PD), but how mutations in this gene lead to neuron death is not yet known. Astrocytes, which are brain cells that su...
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Our funding programs support basic, translational and clinical research from academia and industry.