The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2021Use of LRRK2 and Lysosomal Biomarker Signatures to Differentiate Idiopathic and Monogenetic Parkinson’s Disease
Study Rationale:
As new targeted therapies for Parkinson’s disease (PD) enter clinical trials, it will be important to develop biomarkers that will allow clinicians to match people with PD with... -
Biomarkers, 2021Autoimmune Targeting of Mitochondria as a New Biomarker for Parkinson’s Disease
Study Rationale:
Parkinson’s disease (PD) is a complex, age-related disorder for which there are currently no biomarkers available to diagnose or predict the onset of disease. However, growing... -
Aligning Science Across Parkinson's, 2021Engineering Research-enabling Cells to Fuel Mechanistic Studies of Parkinson’s Disease
Study Rationale:
Induced pluripotent stem cells (iPSCs) have become widely used in the research community to investigate how mutations found in genetic studies of Parkinson’s disease (PD) alter the... -
Target Advancement Program, 2021Targeting the Chemical Modification of DNA to Suppress Neurodegeneration in Parkinson’s Disease
Study Rationale:
Genes can be switched on or off by proteins that add and remove chemical modifications to DNA. We and others have shown that the chemical modification of genes important for... -
Priority Biology, 2021Gene Expression Changes Induced by Alpha-Synuclein
Study Rationale:
Deposits of the alpha-synuclein protein are the key cellular pathology recognized to drive the progression of Parkinson’s disease leading to the death of neurons. The alpha-synuclein... -
Research Grant Supplement, 2021Profiling the Removal of Damaged Mitochondria in Stem Cell-Derived Brain Cells from People with Parkinson’s
Promising Outcomes of Original Grant:
Our previous work has shown that metabolic failure plays a critical role in the pathology of Parkinson’s disease (PD). A plethora of evidence from different...
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Our funding programs support basic, translational and clinical research from academia and industry.